Dermal Peptide Delivery

真皮肽输送

• 批准号: 275955092
• 负责人: Professor Dr. Reinhard Neubert
• 金额: --
• 依托单位: Universitätsklinik und Poliklinik für Dermatologie und Venerologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/275955092?language=en
• 关键词: Dermal; Peptide; Delivery

Because of their hydrophilic properties and high molecular weight compared to small molecules Peptides are mostly unable to penetrate the stratum corneum, the biophysicalic barrier of the human skin. Therefore, they have not been used in dermato-pharmacy and therapy so far. Aim of this project is to investigate how penetration of peptide agents into the skin can be enhanced, in order to be able to use these agents in topical therapy. Tetrapeptides will be used as model peptides after tests of their stability. The followings tests are performed on intact as well as damaged skin regarding penetration enhancing:1. Incorporation into colloidal carrier systems2. Application of penetration enhancer molecules.This project will be realized by interdisciplinary cooperation in between dermatologists, pharmacists and chemists. The results of this project will be the basis for further dermato-pharmaceutical studies with the objective to use oligopeptides and proteins with high molecular mass in transdermal therapy for specific skin disorders.

由于其亲水特性和与小分子相比的高分子量，肽大多无法穿透角质层，即人体皮肤的生物物理屏障。因此，迄今为止它们尚未用于皮肤药剂和治疗。该项目的目的是研究如何增强肽制剂对皮肤的渗透，以便能够在局部治疗中使用这些制剂。经过稳定性测试后，四肽将被用作模型肽。在完整和受损皮肤上进行以下有关渗透增强的测试：1。纳入胶体载体系统2。渗透促进剂分子的应用。该项目将通过皮肤科医生、药剂师和化学家之间的跨学科合作来实现。该项目的结果将成为进一步皮肤药物研究的基础，其目标是使用寡肽和高分子质量的蛋白质进行特定皮肤疾病的透皮治疗。

项目成果

Dermal peptide delivery using enhancer moleculs and colloidal carrier systems. Part II: Tetrapeptide PKEK

使用增强剂分子和胶体载体系统进行真皮肽递送第二部分：四肽 PKEK

• DOI: 10.1016/j.ejpb.2017.12.004
• 发表时间: 2018
• 期刊: European Journal of Pharmaceutics and Biopharmaceutics
• 影响因子: 4.9
• 作者: Neubert RHH;Sommer E;Schölzel M;Tuchscherer B;Mrestani Y;Wohlrab J
• 通讯作者: Wohlrab J

Dermal peptide delivery using enhancer molecules and colloidal carrier systems. Part III: Tetrapeptide GEKG

使用增强剂分子和胶体载体系统进行真皮肽递送第 III 部分：四肽 GEKG

• DOI: 10.1016/j.ejps.2018.08.034
• 发表时间: 2018
• 期刊: European Journal of Pharmaceutical Sciences
• 影响因子: 4.6
• 作者: Sommer E;Neubert RHH;Mentel M;Tuchscherer B;Mrestani Y;Wohlrab J
• 通讯作者: Wohlrab J

Dermal peptide delivery using enhancer molecules and colloidal carrier systems - part V#: Influence of enhancers on the permeation of PKEK through snake skin.

使用增强剂分子和胶体载体系统进行真皮肽递送 - 第五部分

• DOI: 10.1691/ph.2019.8105
• 期刊: Die Pharmazie
• 作者: Förster AC;Neubert RHH
• 通讯作者: Neubert RHH