Neuro MRE (I): High resolution mechanical imaging of elasticity, viscosity and pressure in the human brain

Neuro MRE (I)：人脑弹性、粘度和压力的高分辨率机械成像

• 批准号: 276880906
• 负责人: Privatdozent Dr. Jürgen Braun
• 金额: --
• 依托单位: Berlin Center for Advanced Neuroimaging (BCAN)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/276880906?language=en
• 关键词: Neuro; MRE; resolution; mechanical; imaging

Brain parenchymal viscoelasticity and intracranial pressure are important mechanical parameters influencing cerebral blood flow and ion transport through water diffusion and can thus affect the structural and functional integrity of neurons and glial cells. Currently used imaging-based markers of neurologic disorders such as lesion load on conventional T2-weighted brain magnetic resonance imaging (MRI) in multiple sclerosis (MS) have limited ability in visualizing the intricate structural-functional relationship of brain tissue and quantifying nonovert brain damage. The proposed projects aim at investigating magnetic resonance elastography (MRE) and quantitative MRI for mapping local biophysical properties of brain tissue on a pixel scale taking effects of hydration, blood flow, and activity on viscoelasticity parameters into account. With a dedicated focus on neuroinflammation we will develop methods to investigate the altered functional relationship between brain structure and clinical disability in patients with MS and neuromyelitis optica spectrum disorder (NMOSD). These methods include: real-time MRE of brain and spinal cord, high-resolution 3D multifrequency MRE of full brain and spinal cord as well as complementary quantitative MRI protocols including water diffusion and perfusion-sensitive sequences for in-depth analysis of biophysical properties of the in vivo brain and spinal cord. In synchrony with preclinical research of Neuro-MRE II in mouse models we will bridge the micro- and macro-worlds of biophysical parameters by detecting changes involving cellular networks in the brain affected by neuroinflammatory processes. The overarching aim of this project is to develop multiparametric, quantitative MRI of the human brain to determine biophysical tissue parameters including viscoelasticity, blood perfusion, and water diffusion to better understand and precisely diagnose neuroinflammatory diseases by MRI.

脑实质粘弹性和颅内压是影响大脑血流和通过水扩散的离子转运的重要机械参数，因此会影响神经元和神经胶质细胞的结构和功能完整性。当前使用基于成像的神经系统疾病的标记物，例如在多发性硬化症（MS）中传统的T2加权脑磁共振成像（MRI）上的病变负荷（MRI）具有有限的能力，可以使人可视化脑组织的复杂结构功能关系和量化非疏忽大脑损伤。拟议的项目旨在研究磁共振弹性图（MRE）和定量MRI，用于在像素量表上绘制脑组织的局部生物物理特性，以考虑水合，血流和活性对粘弹性参数的影响。通过专门关注神经炎症，我们将开发方法来研究MS和Optica谱系障碍（NMOSD）患者大脑结构与临床障碍之间的功能关系改变。这些方法包括：大脑和脊髓的实时MRE，全脑和脊髓的高分辨率多频MRE以及互补的定量MRI方案，包括水扩散和灌注敏感序列，用于对体内脑和脊髓的生物物理特性的深入分析。在小鼠模型中与神经元II的临床前研究同步，我们将通过检测涉及受神经炎症过程影响的大脑中细胞网络的变化来弥合生物物理参数的微世界和宏观世界。该项目的总体目的是开发人脑的多参数，定量MRI，以确定生物物理组织参数，包括粘弹性，血液灌注和水扩散，以更好地理解和精确地诊断MRI的神经炎性疾病。