Improved prostate cancer diagnostics and treatment planning with Magnetic ResonanceElastography (MRE), Diffusion Tensor Imaging (DTI) and Chemical Exchange Saturation Transfer (CEST): ex-vivo imaging and translation to an in-vivo application for patients
通过磁共振弹性成像 (MRE)、扩散张量成像 (DTI) 和化学交换饱和转移 (CEST) 改进前列腺癌诊断和治疗计划:离体成像并转化为患者体内应用
基本信息
- 批准号:387074563
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Fellowships
- 财政年份:2017
- 资助国家:德国
- 起止时间:2016-12-31 至 2018-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Motivation:In Germany, prostate cancer (PCa) is the most common tumor in men. Despite the success of multiparametric magnetic resonance imaging (mpMRI) in evaluating PCa, there are significant limitations such as the low specificity for distinguishing benign prostatic hyperplasia and malignant tumors, low sensitivity for detecting extraprostatic tumor extension and moderate inter-reader reliability of radiologists. This project builds on the previous study and also aims to improve non-invasive PCa diagnostics. The innovation of this project consists of expansion and acceleration of diagnostic methods as well as translation to an in-vivo application for patients.Methods:A total of three new MRI techniques will be investigated which will provide quantitative information on viscoelastic properties (magnetic resonance elastography, MRE), structural organization (diffusion tensor imaging, DTI) and physiology (chemical exchange saturation transfer, CEST) of the prostate. Additionally, for the first time, a simultaneous acquisition of DTI and MRE of the prostate will be performed - the so-called DTI-MRE. Subsequently, the examination times can be accelerated and artifacts, e.g., due to involuntary bowel movements, can be reduced for in-vivo applications. These techniques are first studied ex-vivo on ten resected prostatectomy specimens from patients with PCa on an ultra-high-field 9.4 Tesla MRI scanner. Afterwards, a translation to an in-vivo application with ten healthy volunteers and ten patients with PCa on a clinical 3 Tesla MRI scanner will be performed. To evaluate the diagnostic accuracy, results are compared with pathology as the reference standard. Furthermore, the quantitative data is used to develop a 3D visualization software and predictive multivariable logistic regression model for PCa probability determination. Hypothesis and aims:We hypothesize that the addition of a time-efficient DTI-MRE and CEST sequence to current standard mpMRI protocols improves the detection, grading and treatment planning of PCa without a significant additional effort for clinical routine. In the future, patients may benefit from this non-invasive method because complications of transrectal biopsies, such as infections and rectal bleedings, but also unnecessary surgical prostatectomy and its risks, such as incontinence and impotence, can be avoided. Moreover, we hypothesize that the implementation of quantitative data increases the inter-reader reliability of radiologists. In order to make this information actionable for clinical practice, we will visually integrate quantitative data with current standard mpMRI and pathology.
动机:在德国,前列腺癌(PCa)是男性最常见的肿瘤。尽管多参数磁共振成像(mpMRI)在评估PCa方面取得了成功,但仍存在显著的局限性,例如区分良性前列腺增生和恶性肿瘤的特异性较低,检测前列腺外肿瘤扩展的敏感性较低,放射科医师的阅片者间可靠性中等。该项目建立在以前的研究基础上,旨在改善非侵入性PCa诊断。该项目的创新包括扩展和加速诊断方法以及翻译到体内应用patient.Methods:总共有三个新的MRI技术将进行调查,这将提供定量信息的粘弹性(磁共振弹性成像,MRE),结构组织(扩散张量成像,DTI)和生理(化学交换饱和转移,CEST)的前列腺。此外,将首次同时采集前列腺的DTI和MRE-所谓的DTI-MRE。随后,检查时间可以被加速,并且伪影,例如,由于不自主的肠运动,对于体内应用可以减少。这些技术首先在超高场9.4特斯拉MRI扫描仪上对来自PCa患者的10个切除的前列腺切除术标本进行体外研究。之后,将在临床3 T MRI扫描仪上对10名健康志愿者和10名PCa患者进行体内应用转换。为了评估诊断的准确性,将结果与病理学作为参考标准进行比较。此外,定量数据用于开发用于PCa概率确定的3D可视化软件和预测性多变量逻辑回归模型。假设和目的:我们假设,在当前标准mpMRI方案中添加时间效率高的DTI-MRE和CEST序列可改善PCa的检测、分级和治疗计划,而无需对临床常规进行显著的额外努力。在未来,患者可能会受益于这种非侵入性的方法,因为经直肠活检的并发症,如感染和直肠bleeding,但也可以避免不必要的手术切除术及其风险,如失禁和阳痿。此外,我们假设定量数据的实施增加了放射科医师的阅片者之间的可靠性。为了使这些信息可用于临床实践,我们将可视化地将定量数据与当前标准的mpMRI和病理学相结合。
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
In Vivo Quantification of Water Diffusion, Stiffness, and Tissue Fluidity in Benign Prostatic Hyperplasia and Prostate Cancer
- DOI:10.1097/rli.0000000000000685
- 发表时间:2020-08-01
- 期刊:
- 影响因子:6.7
- 作者:Asbach, Patrick;Ro, Sa-Ra;Sack, Ingolf
- 通讯作者:Sack, Ingolf
Diagnostic performance of tomoelastography of the liver and spleen for staging hepatic fibrosis
- DOI:10.1007/s00330-019-06471-7
- 发表时间:2019-11-11
- 期刊:
- 影响因子:5.9
- 作者:Reiter, Rolf;Tzschaetzsch, Heiko;Asbach, Patrick
- 通讯作者:Asbach, Patrick
Prostate cancer assessment using MR elastography of fresh prostatectomy specimens at 9.4 T
- DOI:10.1002/mrm.28127
- 发表时间:2019-12-10
- 期刊:
- 影响因子:3.3
- 作者:Reiter, Rolf;Majumdar, Shreyan;Klatt, Dieter
- 通讯作者:Klatt, Dieter
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Privatdozent Dr. Rolf Otto Reiter其他文献
Privatdozent Dr. Rolf Otto Reiter的其他文献
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{{ truncateString('Privatdozent Dr. Rolf Otto Reiter', 18)}}的其他基金
C02 Wideband dispersion mMRE for the detection of tissue fluidity in precancerous niches
C02 宽带色散 mMRE 用于检测癌前微环境中的组织流动性
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530849360 - 财政年份:
- 资助金额:
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