Coordination Funds

SPP1784的目的是揭开遗传密码中超越经典四字母字母表的隐藏信息层。虽然基于四种典型沃森-克里克核苷的遗传密码序列几十年来一直是公认的范例，但它的一个重要方面最近被推翻了。很明显，DNA中存在额外的核苷，它们建立了第二层信息，例如对分化过程很重要。沿着同样的思路，我们现在开始理解，许多已知的修饰RNA核苷是我们刚刚开始理解的类似“隐藏”程序的一部分。事实上，破译这些修饰的DNA和RNA核苷所体现的修饰的“遗传”密码是目前（化学）生物学中最热门的话题之一。特别是，RNA修饰领域非常明显，甚至比第一个资助期开始时更加活跃。这项协调建议以第一个赠款期间集体努力取得的重大成就为基础。出色的出版记录和会议活动使其具有很高的国际知名度。这些目标将在第二个资助期内进一步实现，并采取一系列措施，包括为对该领域至关重要的分析方法提供中央网络资金，特别是深度测序和LC-MS。该包还包括一个协调包，为协调器提供适当的基础设施。国际会议和研讨会的时间表，以确保博士生和同事的培训将继续进行。为了充分利用所有人力资源，具体模块为青年科学家和青年研究人员的职业生涯开始提供便利，并改善性别平等。

The aim of this SPP1784 is to unveil a hidden layer of information in the genetic code beyond the classical four-letter alphabet. While the sequence genetic code based on the four canonical Watson-Crick nucleosides has been an accepted paradigm for decades, an important aspect of it has recently been overturned. It became clear that additional nucleosides exist in DNA, which establish a second layer of information that is important e.g. to differentiation processes. Along the same line, we now start to understand that the numerous known modified RNA nucleosides are part of a similar “hidden” program that we are just beginning to understand. Indeed, deciphering the modified “genetic” code that is embodied by these modified DNA and RNA nucleosides is currently one of the hottest topics in (Chemical) Biology. In particular, the field of RNA modification is extremely visible, and even more active than at the beginning of the first grant period. This coordination proposal builds on significant achievements of the collective efforts during the first grant period. Outstanding publication records and conference activity have led to high international visibility. These aims will be further pursued during the second funding period, ensured by a bundle of measures including provisions for central network funds for analytical methods crucial to the field, in particular Deep Sequencing and LC-MS. The bundle further includes a coordination package to supply the coordinator with adequate infrastructure. A schedule for international conferences and workshops to ensure training of PhD students and co-workers will be continued. To make full use of all human resources, specific modules facilitate career starts for young scientists and young investigators and improve gender equity.