Coordination Funds

SPP 1784的目的是揭开遗传密码中隐藏的信息层，超越经典的四个字母表。虽然基于四个典型的沃森-克里克核苷的序列遗传密码几十年来一直是一个公认的范式，但它的一个重要方面最近被推翻了。很明显，DNA中存在额外的核苷，这建立了第二层信息，这对分化过程等很重要。沿着同样的思路，我们现在开始明白，许多已知的修饰RNA核苷是一个类似的“隐藏”程序的一部分，我们刚刚开始了解。事实上，破译这些修饰的DNA和RNA核苷所包含的修饰的“遗传”密码是目前（化学）生物学中最热门的话题之一。特别是RNA修饰领域非常引人注目，甚至比第一个资助期开始时更加活跃。这一协调建议是在第一个赠款期集体努力取得重大成就的基础上提出的。杰出的出版记录和会议活动使其在国际上具有很高的知名度。这些目标将在第二个供资期内进一步实现，并通过一系列措施加以确保，包括为对该领域至关重要的分析方法提供中央网络资金，特别是深度测序和LC-MS。将继续安排国际会议和讲习班，以确保对博士生和同事的培训。为了充分利用所有人力资源，专门的模块为青年科学家和青年调查员的职业生涯提供便利，并改善性别平等。

The aim of this SPP1784 is to unveil a hidden layer of information in the genetic code beyond the classical four-letter alphabet. While the sequence genetic code based on the four canonical Watson-Crick nucleosides has been an accepted paradigm for decades, an important aspect of it has recently been overturned. It became clear that additional nucleosides exist in DNA, which establish a second layer of information that is important e.g. to differentiation processes. Along the same line, we now start to understand that the numerous known modified RNA nucleosides are part of a similar “hidden” program that we are just beginning to understand. Indeed, deciphering the modified “genetic” code that is embodied by these modified DNA and RNA nucleosides is currently one of the hottest topics in (Chemical) Biology. In particular, the field of RNA modification is extremely visible, and even more active than at the beginning of the first grant period. This coordination proposal builds on significant achievements of the collective efforts during the first grant period. Outstanding publication records and conference activity have led to high international visibility. These aims will be further pursued during the second funding period, ensured by a bundle of measures including provisions for central network funds for analytical methods crucial to the field, in particular Deep Sequencing and LC-MS. The bundle further includes a coordination package to supply the coordinator with adequate infrastructure. A schedule for international conferences and workshops to ensure training of PhD students and co-workers will be continued. To make full use of all human resources, specific modules facilitate career starts for young scientists and young investigators and improve gender equity.