Structural brain imaging correlates of schizophrenia symptomatology and their genetic background

脑结构成像与精神分裂症症状及其遗传背景的相关性

• 批准号: 277830519
• 负责人: Dr. Esther Walton
• 金额: --
• 依托单位: Department of Psychology
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/277830519?language=en
• 关键词: Structural; brain; imaging; correlates; schizophrenia

The considerable variability of cognitive and clinical symptoms across patients with schizophrenia likely reflects the impact of various etiological factors and limits the search for underlying pathological processes. Investigating more distinct symptoms of the disease could help to study the brain-based correlates and the genetic background of schizophrenia.The research objectives of this project are to investigate a) the structural correlates of negative and positive symptomatology - core symptoms of schizophrenia - and b) the genetics behind both symptom classes and related brain structures. It is planned to use demographic, clinical, genetic and structural imaging data from the Neuro Imaging Genetics Through Meta-Analysis (ENIGMA) consortium. With over 15 international sites, this consortium includes data of over 2000 patients with schizophrenia and an even larger number of healthy controls.Combining advanced imaging, genome-wide and meta-analytical approaches will allow for the investigation of these relationships in a hypothesis-free and standardized manner helping to gain insight into more specific and causal neurobiological mechanisms of the disorder.

精神分裂症患者认知和临床症状的显着差异可能反映了各种病因因素的影响，并限制了对潜在病理过程的探索。调查该疾病更明显的症状可能有助于研究精神分裂症的大脑相关性和遗传背景。该项目的研究目标是调查 a) 阴性和阳性症状（精神分裂症的核心症状）的结构相关性，以及 b) 症状类别和相关大脑结构背后的遗传学。计划使用来自元分析神经影像遗传学 (ENIGMA) 联盟的人口统计、临床、遗传和结构成像数据。该联盟拥有超过 15 个国际站点，包括超过 2000 名精神分裂症患者和更多健康对照的数据。结合先进的成像、全基因组和荟萃分析方法，将能够以无假设和标准化的方式研究这些关系，有助于深入了解该疾病的更具体和因果神经生物学机制。