Label-free investigation of structure-dynamic relations of single membrane receptors using a tip-enhanced Raman scattering approach (A02)

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This project will target specifically the development for a nanoscale and label-free structure-investigation of membrane receptors, potentially even more specific membrane receptor surfaces. By adapting tip-enhanced Raman spectroscopy (TERS) towards the specific requirements of biological membranes, a structural investigation based on vibrational spectroscopy will allow to identify single receptors and eventually unravel structure-function relations once these receptors undergo externally triggered changes. Ultimately, channeling events at a single receptor level can be tracked down under controlled environmental conditions.