Functional plasticity of glutamate receptor channels on hippocampal mossy fiber terminals (B06+)

海马苔藓纤维末端谷氨酸受体通道的功能可塑性（B06）

• 批准号: 279221805
• 金额: --
• 依托单位: Physiologisches Institut
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/279221805?language=en
• 关键词: Functional; plasticity; glutamate; receptor; channels

Glutamate receptor channels of the Kainate type (GluKs) are autoreceptors at presynaptic active zones (AZs) and control plasticity of hippocampal mossy fiber boutons (MFBs) by yet unknown mechanisms. We focus on GluKs, AZs and MFB plasticity. AZs couple presynaptic calcium inflow and vesicle fusion. Changes in size, molecular composition, number and function of AZs may contribute to MFB plasticity. We aim to elucidate nanoscopic protein dynamics at the level of individual AZs, the role of GluKs and the impact of both on MFB plasticity.

红藻氨酸型谷氨酸受体通道（GluKs）是位于突触前活动区（AZ）的自身受体，通过未知的机制控制海马苔藓纤维结（MFB）的可塑性。我们专注于GluKs，AZ和MFB可塑性。AZs耦联突触前钙内流和囊泡融合。AZs的大小、分子组成、数量和功能的改变可能有助于MFB的可塑性。我们的目的是阐明纳米级蛋白质动力学在个人AZ的水平，GluKs的作用和两者对MFB可塑性的影响。