Internet gaming disorder: Microstructural brain alterations and their relation to functionally assessed correlates of reward processing, inhibitory control and the self-concept
网络游戏障碍:大脑微观结构的改变及其与奖励处理、抑制控制和自我概念的功能评估相关性的关系
基本信息
- 批准号:279455351
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:2015
- 资助国家:德国
- 起止时间:2014-12-31 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Accumulating case numbers of internet gaming disorder have moved the condition increasingly into the focus of clinical research within the past 10 years. Yet, adequate therapies and preventive measures, especially for adolescents, are still lacking. Given the high addictive potential of the condition, this proposal focuses on problematic usage of online role-playing games. These offer the simultaneous gaming of multiple users via their graphical agent (avatar) with or against each other in a virtual world. Similarities to substance addictions and pathological gambling point towards alterations in mesocorticolimbic reward processing- as well as prefrontal inhibitory control mechanisms. Diffusion Tensor Imaging (DTI) studies suggest an imbalance between the relatively early maturation of subcortical areas such as the striatum of the limbic reward system and retarded maturation processes in prefrontal control areas to be at the basis of adolescents increased vulnerability for addictive disorders. The early maturation of reward-associated brain regions might entail craving for immediate rewards and increase risk-taking, which cannot be counterbalanced by prefrontal inhibitory control mechanisms due to their delayed development. Seeing the high prevalence of young affected individuals, this explanatory model might also become essential for internet gaming disorder. Reward processing studies on internet gaming addicts showed increased striatal brain activations upon the perception of avatar- and virtual world-related images. The high salience of these cues might have its basis in the compensation of often observed self-concept deficits by an increased identification with the own avatar. Self-concept-related functional Magnetic Resonance Imaging (fMRI) studies suggest the involvement of a fronto-parietal network, e.g. composed of the medial prefrontal cortex (MPFC) as well as the parietal lobe including the Angular Gyrus (AG). Corresponding DTI studies on adolescents showed age-related white matter maturation processes in the superior longitudinal fasciculus, connecting fronto-parietal brain regions. A study of our own research group on online gaming addicts indicated an association of body-related self-concept deficits with AG hypoactivations. In contrast, AG hyperactivations positively correlated with the strength of identification with the own avatar. Connecting to previous research results, the present proposal aims to longitudinally assess the relation between microstructural (DTI) and functional (fMRI) measures investigating reward processing, inhibitory control as well as self-concept aspects in male adolescent and young adult internet gaming addicts.
过去十年来,网络游戏成瘾病例数量的不断增加,使该疾病日益成为临床研究的焦点。然而,仍然缺乏足够的治疗和预防措施,特别是针对青少年。鉴于这种情况具有很高的成瘾性,该提案重点关注在线角色扮演游戏的有问题的使用。这些允许多个用户通过他们的图形代理(化身)在虚拟世界中相互进行或对抗。物质成瘾和病态赌博的相似之处表明中皮质边缘奖励处理以及前额叶抑制控制机制发生了变化。弥散张量成像(DTI)研究表明,皮质下区域(例如边缘奖励系统的纹状体)相对较早的成熟与前额叶控制区域的成熟过程延迟之间存在不平衡,这是青少年更容易患成瘾性疾病的基础。与奖励相关的大脑区域的过早成熟可能会导致对立即奖励的渴望并增加冒险行为,但由于其发育延迟,前额叶抑制控制机制无法抵消这些风险。鉴于年轻受影响个体的高患病率,这种解释模型也可能对网络游戏障碍变得至关重要。对网络游戏成瘾者的奖励处理研究表明,在感知与虚拟形象和虚拟世界相关的图像时,纹状体大脑的激活增加。这些线索的高度显着性可能有其基础,即通过增加对自己的化身的认同来补偿经常观察到的自我概念缺陷。自我概念相关的功能磁共振成像(fMRI)研究表明额顶叶网络的参与,例如由内侧前额叶皮层 (MPFC) 和包括角回 (AG) 的顶叶组成。对青少年进行的相应 DTI 研究显示,连接额顶脑区域的上纵束中的白质成熟过程与年龄相关。我们自己的研究小组对在线游戏成瘾者进行的一项研究表明,与身体相关的自我概念缺陷与 AG 激活不足之间存在关联。相比之下,AG 过度激活与对自己化身的认同强度呈正相关。结合之前的研究结果,本提案旨在纵向评估微观结构(DTI)和功能(fMRI)测量之间的关系,调查男性青少年和年轻成人网络游戏成瘾者的奖励处理、抑制控制以及自我概念方面。
项目成果
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