Regulation of the EphA3 receptor tyrosine kinase in vertebrate development

EphA3受体酪氨酸激酶在脊椎动物发育中的调节

• 批准号: DP0770302
• 负责人: Prof Andrew Boyd
• 金额: $ 12.23万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0770302
• 关键词: Regulation; EphA3; receptor; tyrosine; kinase

The Eph/ephrin system has a critical role in normal embryonic development. Amongst vertebrates, the EphA3 gene is one of the most highly conserved genes in this system with critical roles in development of the visual system and in other developmental processes. Understanding how this gene is regulated will help us to understand the critical role of EphA3 in the basic biology of humans and other animals. This knowledge may also shed light on the basis of congenital abnormalities and other pathological processes and possibly help us to understand how to prevent or treat these conditions.

Eph/ephrin系统在正常胚胎发育中具有关键作用。在脊椎动物中，EphA 3基因是该系统中最高度保守的基因之一，在视觉系统的发育和其他发育过程中具有关键作用。了解这个基因是如何调控的将有助于我们了解EphA 3在人类和其他动物的基础生物学中的关键作用。这些知识也可能揭示先天性异常和其他病理过程的基础，并可能帮助我们了解如何预防或治疗这些疾病。