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Inhibiting tumour growth by targeting EphA3 and disrupting tumour stromal and vascular microenvironment

Inhibiting tumour growth by targeting EphA3 and disrupting tumour stromal and vascular microenvironment
通过靶向 EphA3 并破坏肿瘤基质和血管微环境来抑制肿瘤生长
批准号:
nhmrc : 1049942
负责人:
A/Pr Martin Lackmann
金额:
$43.02万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2015-12-31

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中文摘要
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英文摘要
Tumours consist of cancer cells, tumour blood vessels and connective tissue, all of which are different to normal tissues. Many of the cells making up tumour vessels and connective tissue are recruited, during initial growth and subsequent spreading of tumours, from the bone marrow. Our research will examine the presence and function of the EphA3 receptor on these cells during tumour development and assess how our anti-EphA3 antibody inhibits tumour growth by targeting stroma and vasculature.
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Antibody-based inhibition of ADAM10 as cancer immunotherapy
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  • 财政年份:
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国内基金
海外基金
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  • 项目类别:
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  • 资助金额:
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