EphA2 and EphA3 Maintain Tumour Initiating Cells and are Therapeutic Targets in Brain Cancer

高级别胶质瘤（High-grade glioma， HGG）是最常见的成人脑癌；目前的治疗方法只将生存时间延长了几个月。我们的研究表明脑癌的细胞表面蛋白家族的特异性表达叫做Eph受体。此外，我们已经证明用Eph抗体靶向这些受体可以显著减少脑癌肿瘤的生长。我们现在建议测试针对这些受体的组合，以获得更大的反应和最小的副作用。

High-grade glioma (HGG) is the most common adult brain cancer; current treatments have increased survival times by months only. Our studies have shown brain cancer specific expression of a family of cell surface proteins called Eph receptors. Furthermore we have shown targeting these receptors with Eph antibodies leads to a significant reduction in brain cancer tumour growth. We now propose to test targeting these receptors in combination to achieve greater responses with minimal side effects.