Regulation of angiogenesis by targeting the melanoma microenvironment and its immune cells (B10#)

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We identified how highly efficient anti-tumor immune responses can be initiated by specific activation of melanoma-resident mast cells (MC). Tumor-infiltrating effector T cells (TILs) were recruited by MC-derived CXCL10 and preliminary data indicate that inhibition of angiogenesis is potently participating in this efficient tumor immune control. Thus, the inhibition of angiogenesis as part of tumor immune therapy will be mechanistically investigated with a focus on MC and TILs. Importantly, by support of the CRC tumor control, T-cell recruitment, and inhibition of angiogenesis in mice and humans will be imaged allowing the appropriate adjustments to further optimize treatment of melanoma.