Fibers, non-woven meshes, and hydrogels based on spider silk and magnetic nanoparticles for bio-inspired shaping and filtering systems

基于蜘蛛丝和磁性纳米粒子的纤维、无纺网和水凝胶，用于仿生成型和过滤系统

• 批准号: 283299309
• 负责人: Professor Dr. Thomas Scheibel
• 金额: --
• 依托单位: Lehrstuhl für Biomaterialien
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/283299309?language=en
• 关键词: Fibers; non; woven; meshes; hydrogels

The objective of this project is to establish a scientific and technological basis for novel bio-inspired shaping systems based on hybrids made of magnetic nanoparticles and spider silk proteins. The employed engineered and recombinantly produced spider silk proteins can be covalently cross-linked with specific magnetic nanoparticles using site-specific chemistry, or they can be blended with a variety of magnetic nano particles. Based on the natural behavior of the underlying spider silk proteins, assembly and processing into nano-, micro- and macroscopic fibrillar structures is possible in a controllable manner. Upon coupling or blending with magnetic nanoparticles, the resulting spider silk fibers, fiber meshes, and fibrillar hydrogels will be analyzed concerning their magnetic responsivity, shaping abilities and concerning their applicability exemplary as filter systems with controllable pore sizes.

该项目的目标是为基于磁性纳米颗粒和蜘蛛丝蛋白质混合物的新型生物启发成形系统建立科学和技术基础。所采用的工程化和重组产生的蜘蛛丝蛋白可以使用位点特异性化学与特定的磁性纳米颗粒共价交联，或者它们可以与各种磁性纳米颗粒共混。基于底层蜘蛛丝蛋白的天然行为，可以以可控的方式组装和加工成纳米、微米和宏观纤维状结构。在与磁性纳米颗粒偶联或共混后，将分析所得的蜘蛛丝纤维、纤维网和纤维状水凝胶的磁响应性、成形能力以及它们作为具有可控孔径的过滤系统的示例性适用性。