Effects of emotion and stress on mnemonic binding of contextual information: Brain dynamics and neural substrates

情绪和压力对上下文信息的记忆结合的影响：大脑动力学和神经基质

• 批准号: 283370187
• 负责人: Professor Dr. Mathias Weymar
• 金额: --
• 依托单位: Institut für Psychologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/283370187?language=en
• 关键词: Effects; emotion; stress; mnemonic; binding

An important aspect of episodic memory is the binding of contextual information (e.g., time, place, associative cues) that constitutes the many disparate features of a unified event, a binding mechanism that seems to be compromised in trauma and stress-related disorders (e.g. Acute or Posttraumatic Stress Disorder or Adjustment Disorders). Recent behavioral findings with healthy participants suggest that acute stress indeed impairs the integration of such contextual cues into an (emotional) episodic memory trace, indicating that stress hormones most likely mediate memory context functioning. The planned project builds upon these findings and aims to investigate brain dynamics and neural substrates of the mechanisms underlying long-term mnemonic binding of contextual emotional and neutral information (within and between item binding) in healthy volunteers using dense-array electrocortical (ERPs) and functional hemodynamic measures (fMRI) of human brain activity. The project will be divided into two phases investigating a) the basic neural mechanisms underlying context binding of emotional and neutral information during encoding and retrieval in healthy participants (Phase 1) and b) the role of stress on contextual binding (Phase 2) taking into account temporal dynamics of corticosteroid actions (rapid non-genomic vs slow gene-mediated) and the neural mechanisms underlying these effects.The outcome of this project will impact research on the relationship between emotion, stress and memory. Memory for events and for their associations with other information is essential in everyday life and knowing the factors mediating these processes is crucial particularly with regard to clinical populations, as deficits in linking the traumatic event with appropriate contextual information represents an important vulnerability factor for the development and maintenance of trauma and stressor related disorders.

情景记忆的一个重要方面是情境信息的结合（例如，时间、地点、关联线索），这些线索构成了一个统一事件的许多不同特征，这是一种似乎在创伤和应激相关疾病（例如急性或创伤后应激障碍或适应障碍）中受到损害的结合机制。最近对健康参与者的行为研究结果表明，急性压力确实会损害将这些上下文线索整合到（情感）情景记忆痕迹中，这表明压力激素最有可能介导记忆上下文功能。计划中的项目建立在这些发现的基础上，旨在研究大脑动力学和神经基板的机制，长期记忆结合的上下文情感和中性信息（内和项目之间的绑定）在健康志愿者使用密集阵列皮层电（ERPs）和功能性血流动力学措施（fMRI）的人脑活动。该项目将分为两个阶段，研究a）健康参与者在编码和提取过程中情感和中性信息的背景结合的基本神经机制（阶段1）和B）考虑皮质类固醇作用的时间动力学的压力对背景结合的作用（阶段2（快速非基因组vs慢速基因介导）以及这些效应背后的神经机制。该项目的结果将影响情绪、压力和记忆之间关系的研究。对事件及其与其他信息的关联的记忆在日常生活中是必不可少的，并且了解介导这些过程的因素是至关重要的，特别是对于临床人群，因为将创伤事件与适当的背景信息联系起来的缺陷代表了创伤和应激源相关障碍的发展和维持的重要脆弱性因素。

项目成果

Chronic stress and emotion: Differential effects on attentional processing and recognition memory

• DOI: 10.1016/j.psyneuen.2019.05.008
• 发表时间: 2019-09
• 期刊: Psychoneuroendocrinology
• 影响因子: 3.7
• 作者: Janine Wirkner;C. Ventura-Bort;L. Schwabe;A. Hamm;M. Weymar

Item and source memory for emotional associates is mediated by different retrieval processes

• DOI: 10.1016/j.neuropsychologia.2017.12.015
• 发表时间: 2020-08
• 期刊: Neuropsychologia
• 影响因子: 2.6
• 作者: C. Ventura-Bort;F. Dolcos;J. Wendt;Janine Wirkner;A. Hamm;M. Weymar

Binding neutral information to emotional contexts: Brain dynamics of long-term recognition memory

• DOI: 10.3758/s13415-015-0385-0
• 发表时间: 2016-04
• 期刊: Cognitive, Affective, & Behavioral Neuroscience
• 作者: C. Ventura-Bort;Andreas Löw;J. Wendt;J. Moltó;R. Poy;F. Dolcos;A. Hamm;M. Weymar

Enhanced spontaneous retrieval of cues from emotional events: An ERP study

增强从情绪事件中自发检索线索：一项 ERP 研究

• DOI: 10.1016/j.biopsycho.2019.107742
• 发表时间: 2019
• 期刊: Biological Psychology
• 影响因子: 2.6
• 作者: Ventura-Bort;Wirkner;Dolcos;Weymar
• 通讯作者: Weymar

When neutral turns significant: brain dynamics of rapidly formed associations between neutral stimuli and emotional contexts

• DOI: 10.1111/ejn.13319
• 发表时间: 2016-06
• 期刊: European Journal of Neuroscience
• 影响因子: 3.4
• 作者: C. Ventura-Bort;Andreas Löw;J. Wendt;F. Dolcos;A. Hamm;M. Weymar