High resolution Ultrasound Transmission Tomography

高分辨率超声透射断层扫描

基本信息

项目摘要

The aim of this proposal is to provide a new method for early breast cancer diagnosis: high resolution three-dimensional ultrasound transmission tomography. By imaging the quantitative tissue parameters sound speed and attenuation, it enables new insights in breast cancer diagnosis. The current standard image reconstruction for transmission tomography uses a ray-based algebraic reconstruction approach, which limits the resolution considerably. This restricts the applicability of the method as the detection of small tumors is not possible. In this project, we overcome these limitations by a new iterative reconstruction method based on a more accurate forward modeling with the paraxial approximation. The substantially higher computational demand is tackled by most recent and sophisticated optimization strategies. The objective is to reach one order of magnitude higher resolution while reducing the number of iterations to solve the ill-posed inverse problem by one order of magnitude compared to the current methods. The reduction of iterations together with an efficient implementation on parallel infrastructures like a multi-GPU system allows the reconstruction of high resolution three-dimensional volumes in a clinically relevant time for diagnosis at the same day. The development of a high resolution transmission tomography method is essential for ultrasound applications in medicine. The developed method will be applied in this project to an innovative new imaging modality, "3D Ultrasound Computer Tomography" (USCT) for early breast cancer diagnosis. In previous work, the Karlsruhe Institute of Technology (KIT) developed, built and characterized the world's first 3D USCT. With the current ray-based reconstruction method, the resolution of transmission tomography in 3D USCT is limited to max. 12mm. Establishing the new reconstruction method, the resolution increase of an order of magnitude potentially allows 3D USCT to detect cancers of a size below 5mm, which increases the chance of survival for concerned patients dramatically. By combining the expertise in ultrasound system development (KIT) and ill-posed inverse problems (University Heidelberg) we are prepared to address this research problem. The developed method will be evaluated by simulated, phantom and in-vivo data. This lays the foundation for following clinical studies to evaluate the sensitivity and specificity of the method. Establishing the high resolution transmission tomography reconstruction would present a major breakthrough. It potentially makes 3D USCT a highly desirable and economic modality for clarification of suspicious diagnoses or - in future - even as screening modality for early breast cancer detection.
本方案的目的是为乳腺癌早期诊断提供一种新的方法:高分辨率三维超声透射层析成像。通过成像定量组织参数的声速和衰减,使其能够在乳腺癌诊断中获得新的见解。目前用于透射层析成像的标准图像重建方法采用基于射线的代数重建方法,这大大限制了分辨率。这限制了该方法的适用性,因为无法检测到小肿瘤。在这个项目中,我们通过一种新的迭代重建方法克服了这些限制,该方法基于更精确的近轴近似正演模拟。最新和最复杂的优化策略解决了显著更高的计算需求。目标是达到比现有方法高一个数量级的分辨率,同时将求解不适定反问题的迭代次数减少一个数量级。迭代次数的减少以及在并行基础设施(如多GPU系统)上的高效实施允许在临床相关时间内重建高分辨率三维体积,以便在同一天进行诊断。高分辨率透射层析成像方法的发展对于超声在医学上的应用是至关重要的。开发的方法将在该项目中应用于一种创新的新成像模式--用于乳腺癌早期诊断的三维超声计算机断层扫描(USCT)。在之前的工作中,卡尔斯鲁厄理工学院(KIT)开发、建造了世界上第一台3D USCT,并对其进行了表征。在现有的基于射线的重建方法中,三维超声SCT中的透射层析成像的分辨率被限制在最大。12 mm。在建立新的重建方法后,分辨率提高了一个数量级,潜在地使3D USCT能够检测到5 mm以下的癌症,这大大增加了相关患者的生存机会。通过结合超声系统开发(KIT)和病态逆问题(海德堡大学)的专业知识,我们准备解决这一研究问题。所开发的方法将通过模拟、体模和体内数据进行评估。这为后续的临床研究评估该方法的敏感性和特异性奠定了基础。建立高分辨率的透射层析重建将是一个重大突破。这可能使3D USCT成为澄清可疑诊断的一种非常理想和经济的方式,或者--甚至在未来--作为早期乳腺癌检测的筛查方式。

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Experimental analysis of ray-based sound speed reconstruction algorithms for phase aberration corrected USCT SAFT imaging
基于射线的相位差校正USCT SAFT成像声速重建算法的实验分析
  • DOI:
    10.1117/12.2512955
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    T. Hopp;F. Zuch;M. Zapf;H. Gemmeke;N.V. Ruiter
  • 通讯作者:
    N.V. Ruiter
Redatuming of 2-D Wave Fields Measured on an Arbitrary-Shaped Closed Aperture
任意形状闭孔测量的二维波场的重定
USCT Image Reconstruction: Acceleration using Gauss-Newton Preconditioned Conjugate Gradient
USCT 图像重建:使用高斯-牛顿预条件共轭梯度加速
  • DOI:
    10.5445/ir/1000079815
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    H. Wang;H. Gemmeke;T. Hopp;J. Hesser
  • 通讯作者:
    J. Hesser
Wave equation based transmission tomography
基于波动方程的透射断层扫描
  • DOI:
    10.1109/ultsym.2016.7728829
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    0
  • 作者:
    H. Gemmeke;L. Althaus;K. W. A. van Dongen;H. Egger;J. Hesser;J. Mayer;N.V. Ruiter;M. Zapf;T. Hopp
  • 通讯作者:
    T. Hopp
Experimental evaluation of straight ray and bent ray phase aberration correction for USCT SAFT imaging
  • DOI:
    10.1117/12.2292895
  • 发表时间:
    2018-03
  • 期刊:
  • 影响因子:
    0
  • 作者:
    T. Hopp;M. Zapf;H. Gemmeke;N. Ruiter
  • 通讯作者:
    T. Hopp;M. Zapf;H. Gemmeke;N. Ruiter
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Professor Dr. Jürgen Hesser其他文献

Professor Dr. Jürgen Hesser的其他文献

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{{ truncateString('Professor Dr. Jürgen Hesser', 18)}}的其他基金

Computerunterstützung für komplexe vaskuläre Interventionen
复杂血管介入治疗的计算机支持
  • 批准号:
    25966250
  • 财政年份:
    2007
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Combination of Fast, Robust TV-based Deconvolution with Variational Segmentation for Microscopic Data
快速、鲁棒的基于电视的反卷积与微观数据的变分分割相结合
  • 批准号:
    14024299
  • 财政年份:
    2005
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Localisation and visualisation of biological markers and tracking of structures in living cells
生物标记的定位和可视化以及活细胞结构的跟踪
  • 批准号:
    5391909
  • 财政年份:
    2003
  • 资助金额:
    --
  • 项目类别:
    Priority Programmes
Trainingssystem für die Kardiologie II
心脏病学培训系统II
  • 批准号:
    5360154
  • 财政年份:
    2002
  • 资助金额:
    --
  • 项目类别:
    Research Grants

相似海外基金

Multiparametric Tissue Characterization for Breast Cancer Screening Using Transmission and Reflection Ultrasound Tomography
使用透射和反射超声断层扫描进行乳腺癌筛查的多参数组织表征
  • 批准号:
    10675896
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Towards Low-Clutter High-Resolution Ultrafast Ultrasound Imaging of Large Volumes in the Context of Motion Using a Coded Parallel Transmission Scheme
使用编码并行传输方案实现运动背景下大体积低杂波高分辨率超快超声成像
  • 批准号:
    519312-2018
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Towards Low-Clutter High-Resolution Ultrafast Ultrasound Imaging of Large Volumes in the Context of Motion Using a Coded Parallel Transmission Scheme
使用编码并行传输方案实现运动背景下大体积低杂波高分辨率超快超声成像
  • 批准号:
    519312-2018
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Postgraduate Scholarships - Doctoral
Dynamic mapping of vessels in soft tissue in transmission and reflection measurement, as a hybrid method from ultra-wideband and ultrasound signals forthe non-invasive determination of the blood pressure.
在透射和反射测量中对软组织中的血管进行动态映射,作为超宽带和超声信号的混合方法,用于无创测定血压。
  • 批准号:
    397662162
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Towards Low-Clutter High-Resolution Ultrafast Ultrasound Imaging of Large Volumes in the Context of Motion Using a Coded Parallel Transmission Scheme
使用编码并行传输方案实现运动背景下大体积低杂波高分辨率超快超声成像
  • 批准号:
    519312-2018
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
    Postgraduate Scholarships - Doctoral
Preoperative evaluation of bone quality for dental implantation using an ultrasound axial transmission device
超声轴向传输装置术前评估牙种植骨质量
  • 批准号:
    16K20540
  • 财政年份:
    2016
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Acoustic imaging using air-coupled focus-type P(VDF/TrFE) transducers on non contact ultrasound by through-transmission method.
使用空气耦合聚焦型 P(VDF/TrFE) 换能器通过透射方法​​对非接触式超声进行声学成像。
  • 批准号:
    16K06378
  • 财政年份:
    2016
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Study on wireless power transmission using convergent ultrasound beam
利用会聚超声波束进行无线电力传输的研究
  • 批准号:
    15K12074
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Seeing the Links in the Speaker-Hearer Chain: An investigation of the transmission of articulatory variation using Ultrasound Tongue Imaging.
查看说话者-听者链中的链接:使用超声波舌头成像研究发音变异的传播。
  • 批准号:
    ES/I036400/1
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:
    Research Grant
Ultrasound Transmission Beam Computed Tomography for the In-situ Sound Speed Quantitative Diagnostic Imaging of Abdominal Tissue
超声透射束计算机断层扫描用于腹部组织原位声速定量诊断成像
  • 批准号:
    17560367
  • 财政年份:
    2005
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
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