Revealing the Role of Postnatal Theta Rhythm in Establishing Memory Consolidation Mechanism during REM Sleep

我们发现，无梦小鼠在恐惧条件反射过程中表现出低冻结行为，这可能是由于快速眼动睡眠的长期丧失。 早期的数据表明，在后调节睡眠期间，他们的REM睡眠时间会进一步缩短，这会影响记忆的巩固。此外，海马体θ波在快速眼动睡眠期间表现出低光谱功率，这是记忆储存所必需的。无梦猫在两周内表现出更大的记忆丧失，表明与野生型同窝仔相比记忆衰退更快。在无梦状态下，远距离记忆提取时，前扣带皮层（ACC）中c-fos阳性细胞数量较少，这与较低的冻结行为相一致。

We found dreamless mice display low freezing behavior during fear conditioning, which could be due to chronic loss of REM sleep. Early data indicates their REM sleep duration gets further shortened during the postconditioning sleep, which can influence the memory consolidation. Furthermore, hippocampal theta shows low spectral power during REM sleep, that required for memory storage.Indeed dreamless show low-freezing behavior one day or two weeks later. Dreamless shows a larger loss of memory at two weeks time, indicating faster memory decay compared with wild type littermates . Upon remote memory retrieval, the number of c-fos positive cells in the anterior cingulate cortex (ACC), a center for remote memory storage, was low in dreamless, which agrees with lower freezing behavior.