Revealing the Role of Postnatal Theta Rhythm in Establishing Memory Consolidation Mechanism during REM Sleep

我们发现不做梦的老鼠在恐惧条件反射中表现出较低的冻结行为，这可能是由于快速眼动睡眠的慢性丧失。早期数据表明，他们的快速眼动睡眠时间在后处理睡眠中进一步缩短，这可能会影响记忆的巩固。此外，海马体θ波在快速眼动睡眠期间显示出较低的频谱功率，这需要记忆存储。确实，无梦者在一天或两周后表现出低冻行为。在两周的时间里，无梦的幼崽表现出更大的记忆损失，这表明与野生型幼崽相比，它们的记忆衰退速度更快。在远端记忆检索中，无梦时，远端记忆存储中心前扣带皮层（ACC）中c-fos阳性细胞的数量较低，这与较低的冻结行为一致。

We found dreamless mice display low freezing behavior during fear conditioning, which could be due to chronic loss of REM sleep. Early data indicates their REM sleep duration gets further shortened during the postconditioning sleep, which can influence the memory consolidation. Furthermore, hippocampal theta shows low spectral power during REM sleep, that required for memory storage.Indeed dreamless show low-freezing behavior one day or two weeks later. Dreamless shows a larger loss of memory at two weeks time, indicating faster memory decay compared with wild type littermates . Upon remote memory retrieval, the number of c-fos positive cells in the anterior cingulate cortex (ACC), a center for remote memory storage, was low in dreamless, which agrees with lower freezing behavior.