权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

3D MRI for a comprehensive in-vivo analysis of fluid-structure interaction in carotid artery plaques

3D MRI 用于颈动脉斑块中流体-结构相互作用的全面体内分析

基本信息

批准号：
298934133
负责人：
Professor Dr. Andreas Harloff
金额：
--
依托单位：
Arbeitsbereich Medizinphysik
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2016
资助国家：
德国
起止时间：
2015-12-31 至 2019-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/298934133?language=en
关键词：
3D MRI comprehensive vivo analysis

项目摘要

Internal carotid artery (ICA) stenosis is one major source of ischemic stroke. Current routine strategies focus on the treatment of cardiovascular risk factors, platelet inhibition and vessel recanalization in stenosis >40% NASCET criteria. However, additional factors that predispose to plaque rupture (i.e. plaque composition and local hemodynamics), are currently neglected. In an attempt to optimize individual risk stratification and stroke prevention we aim to determine hemodynamic factors that independently lead to plaque development, progression and finally rupture. Therefore, a comprehensive assessment of plaques and hemodynamics is planned in high-risk patients in order to study fluid-structure interaction over a three-year period. This will be achieved by establishing a new MRI protocol providing 3D high-resolution multi-contrast plaque imaging, analysis of local hemodynamics based on 4D flow MRI and the generation of personalized models of vessel wall structure and hemodynamics based on this data. We hypothesize that critical wall shear stress (WSS) is responsible for initial atherosclerosis and plaque development whereas mechanical stress and individual plaque composition determine plaque rupture at later stages. Accordingly, these risk factors would provide a completely new approach for the treatment of carotid stenosis and thus prevention of future ischemic stroke.

颈内动脉(ICA)狭窄是缺血性卒中的主要来源之一。目前的常规策略侧重于心血管危险因素的治疗、血小板抑制和血管再通，符合40%NASCET标准。然而，其他易导致斑块破裂的因素(即斑块成分和局部血流动力学)目前被忽视。为了优化个体风险分层和卒中预防，我们的目标是确定独立导致斑块发展、进展和最终破裂的血流动力学因素。因此，计划对高危患者的斑块和血流动力学进行全面评估，以便在三年内研究流体-结构相互作用。这将通过建立一种新的MRI协议来实现，该协议提供3D高分辨率多对比度斑块成像，基于4D Flow MRI对局部血流动力学进行分析，并基于这些数据生成血管壁结构和血流动力学的个性化模型。我们假设临界壁切应力(WSS)是初始动脉粥样硬化和斑块形成的原因，而机械应力和个别斑块组成决定了斑块在后期破裂。因此，这些危险因素将为颈动脉狭窄的治疗提供一种全新的途径，从而预防未来的缺血性中风。