Comprehensive association analysis of genomic mutations affecting food selection behavior and its modeling

影响食物选择行为的基因组突变综合关联分析及其建模

• 批准号: 21K11735
• 负责人: 於保 祐子
• 金额: $ 2.5万
• 依托单位: Jissen Women's University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K11735/
• 关键词: 遺伝栄養学; ゲノム関連解析; バイオインフォマティクス; 個別栄養学; 食行動; 栄養遺伝学

本研究は、個別全ゲノム情報と食選択行動との関連解析を行いその結果をモデル化する事により、個人の食行動に影響する遺伝学的背景を明らかにする事で、個別栄養学に必要な遺伝学的情報を拡充しその新たな展開を図る目的で行う。まず食事記録に記載された食選択行動と個別ゲノム情報との関連解析を行って候補遺伝子を特定する。次にこれらの遺伝子が関与する代謝経路・情報伝達経路や生体分子相互作用を示す分子レベルモデルを作成する。各人がゲノム情報を得てそれにあった食事指導・支援を受ける個別栄養学は、広く社会的関心が高い分野である。本研究は、従来解析させることが少なかった食選択行動に注目し、個別全ゲノム情報との網羅的関連解析を行いその結果をモデル化する事により、栄養指導・栄養教育などに資する新たな知見を得るものである。本年度は前年度の予備的研究に引き続いて、タンパク質を多く含む食品の忌避につながるアミノ酸、アンモニアと窒素代謝に注目して研究を行った、全ゲノム解析の前段階として、予備的研究結果や症例報告文献調査結果から得られた情報をもとに食選択行動との関連が推定される候補遺伝子を25程度選択した。次にこれら遺伝子が関与する複数の代謝経路の相互関係を明らかにし、更にその近傍で作用する遺伝子を選び全体で１００程度の遺伝子からなる代謝マップをモデル化した。また、次年度の全ゲノム解析に向けた情報処理端末の整備をおこなった。

The purpose of this study is to understand the background of the study of the behavior of food and food in this study. the purpose of this study is to understand the background of the study of food activities and personal food activities in this study. the purpose of the new program is to launch a new program for the purpose of launching a new program. To keep a record of food records, to keep track of food and food activities, please do not know how to do this, and to analyze your information. In the second place, the interaction of living molecules shows that the molecules are formed. Everyone is grateful to be informed of food guidance and support for students to learn from others and the differences between the hearts and minds of the society. The purpose of this study is to analyze the behavior and behavior of food consumers, and to analyze the results of the whole information network. The results of this study are related to the results of this study. In this study, the purpose of this study is to analyze the behavior of food consumers, and the results of this study. In this year's previous year, the study of the equipment in the previous year has been conducted in the first part of this year. According to the results of the study, the case report, the literature report, the results of the study, the results of the case report, the literature report, the results of the study, the results of the case report, the literature report, the results of the literature, the results of the study, the results of the case report, the literature report, the results of the literature, the results of the study, the results of the case report, the literature report, the results of the literature, the results of the study, the results of the case report, the literature report, the results of the literature report, the results of the literature report The sub-system and the complex system are used to understand each other, and to select the whole 100-degree sub-system. In the next year, we will make a full analysis of the situation to reason with you at the end of the day.