What is the purpose of sleep? A study based on phagocytic elimination of synapses by microglia.

睡眠的目的是什么？

• 批准号: 20K06856
• 负责人: Choudhury Emamussalehin
• 金额: $ 2.75万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K06856/
• 关键词: Microglia; MyD88; LPS; Delirium; Cognition; Dopamine receptor; Sleep; ミクログリア; ドーパミン; せん妄; 睡眠; モノアミン; うつ; 行動実験; ノックアウトマウス; シナプス; 学習; 記憶; 社会行動; サーカディアンリズム; 貪食; 学習記憶

项目成果

Bromovalerylurea modulates GABAA receptor-mediated inhibitory neurotransmission while inducing sleep.

Bromovalerylurea 在诱导睡眠的同时调节 GABAA 受体介导的抑制性神经传递。

• DOI: 10.1016/j.bbrc.2022.11.062
• 发表时间: 2023
• 期刊: Biochem Biophys Res Commun.
• 作者: Takeda H;Yoshimura Y;Takagi M;Sato A;Kihara N;Choudhury ME;Yano H;Tanaka J.
• 通讯作者: Tanaka J.

Treadmill Exercise as a Preventive Measure Against Age-Related Anxiety and Social Behavioral Disorders in Rats: When Is It Worth Starting?

• DOI: 10.5535/arm.22105
• 发表时间: 2022-12
• 期刊: Annals of rehabilitation medicine
• 作者: Taguchi S;Choudhury ME;Mikami K;Utsunomiya R;Yano H;Tanaka J
• 通讯作者: Tanaka J

Microglia and the Aging Brain: Are Geriatric Microglia Linked to Poor Sleep Quality?

• DOI: 10.3390/ijms22157824
• 发表时间: 2021-07-22
• 期刊: International journal of molecular sciences
• 影响因子: 5.6
• 作者: Choudhury ME;Miyanishi K;Takeda H;Tanaka J
• 通讯作者: Tanaka J

Acute neuroinflammation triggers a dopaminergic surge: a D1 dopamine receptors mediated compensatory role against inhibited spontaneous activity and sleep disturbances

急性神经炎症引发多巴胺能激增：D1 多巴胺受体介导对自发活动抑制和睡眠障碍的代偿作用

• 发表时间: 2022
• 作者: Iwasawa;R.;Murabe;N.;Hayashi;T.;Sakurai;M.;Choudhury Mohammed E
• 通讯作者: Choudhury Mohammed E

Anti-inflammatory effects of dopamine on microglia and a D1 receptor agonist ameliorates neuroinflammation of the brain in a rat delirium model

• DOI: 10.1016/j.neuint.2023.105479
• 发表时间: 2023-01
• 期刊: Neurochemistry International
• 影响因子: 4.2
• 作者: Yuki Nishikawa;Mohammed E. Choudhury;Kanta Mikami;Taisei Matsuura;M. Kubo;M. Nagai;S. Yamagishi;Tomomi Doi;Manami Hisai;Haru Yamamoto;Chisato Yajima;Tasuku Nishihara;Naoki Abe;Hajime Yano;Toshihiro Yorozuya;Junya Tanaka