The role of non-allelic gene conversion in the evolution of Transposable Elements

非等位基因转换在转座元件进化中的作用

• 批准号: 20K06761
• 负责人: FAWCETT JEFFREY
• 金额: $ 2.75万
• 依托单位: Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K06761/
• 关键词: Transposable Elements; gene conversion; Transposable Element; Gene conversion; evolution

Transposable Elements are thought to be key drivers of evolution and have most likely contributed to the rewiring of regulatory networks. In particular, we previously argued that non-allelic gene conversion between TEs likely contributes not only to the evolution of TEs, but also to the rewiring of regulatory networks via TEs. The drastic increase in whole-genome sequence data of various different species in the recent years provides the opportunity to understand the evolution of TEs, including the occurrence of non-allelic gene conversion and their contribution to genome evolution, in great detail that was not possible before. In this study, we have been exploring the evolutionary dynamics of TEs by theory, computer simulation using a previously developed framework, and genomic data analysis using genome sequences of various mammal and plant species. In particular, we have been able to show the contribution of the differential activity of different TE families to genome size evolution, genome structure, and centromere evolution in plant species.

转座因子被认为是进化的关键驱动力，并且很可能有助于调节网络的重新布线。特别是，我们以前认为，TE之间的非等位基因转换可能不仅有助于TE的进化，而且还有助于通过TE重新连接调控网络。近年来，各种不同物种的全基因组序列数据的急剧增加提供了了解TE进化的机会，包括非等位基因转换的发生及其对基因组进化的贡献，这在以前是不可能的。在这项研究中，我们一直在探索TE的进化动力学的理论，计算机模拟使用以前开发的框架，和基因组数据分析使用各种哺乳动物和植物物种的基因组序列。特别是，我们已经能够显示不同TE家族的差异活性对植物物种的基因组大小进化、基因组结构和着丝粒进化的贡献。

项目成果

The role of gene conversion between Transposable Elements in rewiring regulatory systems

转座元件之间的基因转换在重新布线调控系统中的作用

• 发表时间: 2021
• 作者: Jeffrey Fawcett;Hideki Innan
• 通讯作者: Hideki Innan