Reconstruction of dose distributions using PET images in heavy ion therapy

重离子治疗中使用 PET 图像重建剂量分布

• 批准号: 20K08066
• 负责人: Mohammadi Akram
• 金额: $ 2.66万
• 依托单位: National Institutes for Quantum Science and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K08066/
• 关键词: dose reconstruction; PET image; ion therapy

A method for prediction of dose profiles from PET images for 11C and 15O ion beams were developed. The depth dose was measured for both ion beams with mono-energetic and poly-energetic conditions in the carbon therapy facility of the Heavy Ion Medical Accelerator in Chiba (HIMAC). The PET images were obtained for an irradiated polymethyl methacrylate (PMMA) phantom with both beams under the same conditions using a prototype PET system. The results of the mono-energetic beams were used for prediction of the dose profiles for the poly-energetic beams and the predicted dose profiles were in overall good agreement with the measured ones.

开发了从PET图像中预测11C和15o离子束的剂量谱的方法。在千叶（HIMAC）中重离子医疗加速器的碳治疗设施中，对两个离子束的深度剂量均可测量带有单能和聚能量条件的离子束。使用原型PET系统，在相同条件下，在相同条件下，获得了辐照式聚甲基丙烯酸酯（PMMA）幻影的PET图像。单能梁的结果用于预测聚能梁的剂量谱，并且预测的剂量曲线与测量的剂量曲线总体上是良好的一致性。

项目成果

PET-based range verification of 11C ion beam with SOBP

使用 SOBP 对 11C 离子束进行基于 PET 的范围验证

• 发表时间: 2022
• 作者: Kawaguchi N;Miyagawa M;Matsuoka M;Okada T;Kido T;Moriya T;Ohnishi K;Ishimura H;Kido T.;Akram Mohammadi
• 通讯作者: Akram Mohammadi

Development of dual-ended depth-of-interaction detectors using laser-induced crystals for small animal PET systems

使用激光诱导晶体开发用于小动物 PET 系统的双端交互深度探测器

• DOI: 10.1088/1361-6560/ac18fc
• 发表时间: 2021
• 期刊: Physics in Medicine and Biology
• 影响因子: 3.5
• 作者: Mohammadi Akram;Inadama Naoko;Nishikido Fumihiko;Yamaya Taiga
• 通讯作者: Yamaya Taiga