Depression and subgroups - analysis of vascular MRI parameters in different subgroups of depression

抑郁症与亚组——抑郁症不同亚组血管MRI参数分析

• 批准号: 314835879
• 负责人: Privatdozentin Dr. Uta Hanning
• 金额: --
• 依托单位: Klinik und Poliklinik für Neuroradiologische Diagnostik und Intervention
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/314835879?language=en
• 关键词: Depression; subgroups; analysis; vascular; MRI

There is a high heterogeneity of biological factors that influence the development of depression. Up to now most of the studies focused on the relationship between vascular risk factors and late-onset - depression without considering the different subgroups of depression. The bi-directional link between late-onset - depression and cardiovascular risk factors is known and the hypothesis of vascular depression established. The concept of depression subtypes postulates that each may relate to the risk of developing CVD in a specific way. The aim of the current project is to investigate and analyse vascular brain changes in patients with depression in different subgroups and to validate if the hypothesis of the vascular depression can also be applied on depression subgroups. Evidence for the influence of vascular risk factors on subgroups of depression could lead to a significant optimization of therapy.

影响抑郁症发展的生物因素具有高度的异质性。到目前为止，大多数研究都集中在血管危险因素与迟发性抑郁症的关系上，而没有考虑抑郁症的不同亚组。迟发性抑郁症和心血管危险因素之间的双向联系是已知的，并建立了血管性抑郁症的假说。抑郁症亚型的概念假定，每一种亚型都可能以特定的方式与发生心血管疾病的风险有关。本项目的目的是调查和分析不同亚组抑郁症患者的脑血管改变，并验证血管性抑郁症假说是否也适用于抑郁症亚组。血管危险因素对抑郁症亚组的影响的证据可能会导致治疗的显著优化。

项目成果

Computed Tomographic Blend Sign Is Associated With Computed Tomographic Angiography Spot Sign and Predicts Secondary Neurological Deterioration After Intracerebral Hemorrhage

• DOI: 10.1161/strokeaha.116.014068
• 发表时间: 2017-01-01
• 期刊: STROKE
• 影响因子: 8.3
• 作者: Sporns, Peter B.;Schwake, Michael;Hanning, Uta
• 通讯作者: Hanning, Uta

Computed Tomography Perfusion Improves Diagnostic Accuracy in Acute Posterior Circulation Stroke

• DOI: 10.1159/000443618
• 发表时间: 2016-01-01
• 期刊: CEREBROVASCULAR DISEASES
• 影响因子: 2.9
• 作者: Sporns, Peter;Schmidt, Rene;Hanning, Uta
• 通讯作者: Hanning, Uta