Development of Pulse Acquisition System for Accurate Beam Quality Measurement of Multi-ion Therapy and for Accurate Prediction of Biological effect

开发脉冲采集系统，用于多离子治疗的精确束流质量测量和生物效应的准确预测

• 批准号: 20K16776
• 负责人: LEE SUNGHYUN
• 金额: $ 2.5万
• 依托单位: Yamagata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K16776/
• 关键词: Carbon ion radiotherapy; Beam quality; Microdosimetry; Pulse analysis; Multi-ion therapy; Pulse acquisition system; Biological effect

This study aims to accurately measure the beam quality of carbon ions using a microdosimeter in carbon ion therapy. In the MCA currently used to measure the energy spectrum according to the magnitude of the measured pulse signal, it has been confirmed that the signal in the low energy region is unstable, so we try to directly acquire the pulse and directly process the signal without using the MCA. This work will include filtering accompanied by noise rejection using Fourier transforms for signal processing. Through securing a more accurate energy spectrum, we intend to contribute to the treatment of cancer patients by more accurately measuring the quality of the beam of carbon ion therapy.

这项研究的目的是在碳离子治疗中使用微剂量计准确测量碳离子的束流质量。在目前使用的根据测量的脉冲信号的大小来测量能量谱的MCA中，已经确认了低能区的信号是不稳定的，所以尝试直接采集脉冲并直接对信号进行处理，而不使用MCA。这项工作将包括在信号处理中使用傅立叶变换进行伴随噪声抑制的滤波。通过确保更准确的能谱，我们打算通过更准确地测量碳离子治疗束的质量来为癌症患者的治疗做出贡献。

项目成果

University of Wollongong/Centre for Medical Radiation Physics(オーストラリア)

卧龙岗大学/医学辐射物理中心（澳大利亚）

Predicting the Biological Effects of Human Salivary Gland Tumour Cells for Scanned 4He-, 12C-, 16O-, and 20Ne-Ion Beams Using an SOI Microdosimeter

使用 SOI 微剂量计预测 4He、12C、16O 和 20Ne 离子束扫描对人唾液腺肿瘤细胞的生物学效应

• DOI: 10.3390/app12126148
• 发表时间: 2022
• 期刊: Applied Sciences
• 作者: Lee Sung Hyun;Mizushima Kota;Yonai Shunsuke;Matsumoto Shinnosuke;Mizuno Hideyuki;Nakaji Taku;Kohno Ryosuke;Iwata Yoshiyuki;Shirai Toshiyuki;Pan Vladimir;Kok Angela;Povoli Marco;Tran Linh T.;Rosenfeld Anatoly B.;Suzuki Masao;Inaniwa Taku
• 通讯作者: Inaniwa Taku