Beam Quality Determination of Ultra High Energy Neutrons

超高能中子的束流质量测定

• 批准号: 63480248
• 负责人: INADA Tetsuo
• 金额: $ 2.5万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-63480248/
• 关键词: High energy neutrons; Dose distribution; RBE; 50% dose depth; Multicell spheroid; 細胞致死効果; RBE; スフェロイド細胞; 中性子線; 高エネルギー; 生物学的効果比(RBE)

As ultra high energy neutron facility was constructed at PARMS, University of Tsukuba, to produce a neutron beam superior to an X ray beam generated by a modern linac in terms of dose distribution. This has been achieved using the reaction on a thick uranium target struck by 500 MeV proton beam from the booster-synchrotron of High Energy Physics Laboratory. The percent depth dose of this neutron beam is nearly equivalent to that of X-rays at around 20 MV and the dose rate of 15cGy per minute. Relative biological effectiveness of this neutron beam has been estimated on the cell killing effect by the use of HMV-I cell line. Resultant survival curve of cells after the neutron irradiation shows the shoulder with n and Dq of 8 and 2.3 Gy, respectively. RBE value at 10 ^2 survival level for the present neutron, compared with ^<137> Cs gamma -rays is 1.24. The result suggests that the biological effects of high energy neutrons are not practically large enough whenever the depth dose distri bution of neutrons becomes superior to high energy linac X-rays.

筑波大学 PARMS 建造了超高能中子设施，产生的中子束在剂量分布方面优于现代直线加速器产生的 X 射线束。这是利用高能物理实验室助推同步加速器发出的 500 MeV 质子束撞击厚铀靶上的反应来实现的。这种中子束的深度剂量百分比几乎相当于 20 MV 左右的 X 射线，剂量率为每分钟 15cGy。已通过使用 HMV-I 细胞系对细胞杀伤效果评估了该中子束的相对生物有效性。中子照射后细胞的存活曲线显示n和Dq分别为8和2.3 Gy的肩部。与^<137>Cs伽玛射线相比，当前中子在10^2存活水平下的RBE值为1.24。结果表明，只要中子的深度剂量分布优于高能直线加速器 X 射线，高能中子的生物效应实际上就不够大。

项目成果

T. Inada, et al.: "Beam Quality Determination of Ultra High Energy Neutrons." Journal of Radiaion Research. 30. 75 (1989)

T. Inada 等人：“超高能中子的束质量测定”。

稲田哲雄 他: "超高速中性子線の線量および線質特性" 日本医学放射線学会雑誌.

Tetsuo Inada 等：“超快中子束的剂量和辐射质量特性”日本医学放射学会杂志。

稲田 哲雄: "超高エネルギ-中性子線の線量および線質特性" 日本医学射放線学会雑誌. 50. 58-65 (1990)

Tetsuo Inada：“超高能中子束的剂量和辐射质量特性”日本医学放射学会杂志 50. 58-65 (1990)。

Hideo Tatsuzaki: "Early skin reaction following superficial proton irradiation" Journal of Radiation Research.

Hideo Tatsuzaki：“浅表质子照射后的早期皮肤反应”辐射研究杂志。

稲田 哲雄: "超高エネルギ-中性子線の線量および線質特性" 日本医学放射線学会雑誌. 50. 58-65 (1990)

Tetsuo Inada：“超高能中子束的剂量和辐射质量特性”日本医学放射学会杂志 50. 58-65 (1990)。