Generalized morphological modeling of aggregating, filamentous microorganisms

聚集丝状微生物的广义形态学模型

• 批准号: 315384307
• 负责人: Professor Dr.-Ing. Heiko Briesen
• 金额: --
• 依托单位: Lehrstuhl für Systemverfahrenstechnik
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/315384307?language=en
• 关键词: Generalized; morphological; modeling; aggregating; filamentous

Filamentous microorganisms are widely used in industry for biotechnological production of antibiotics, organic acids, and proteins. It is well-known that processing conditions, especially hydrodynamics, affect the morphology of microorganisms. They may appear in form of freely dispersed hyphae, flocs/clumps, or pellets. In turn, the morphology strongly affects the production rate and therefore the economics of the process. Mathematical models can provide the means of a better understanding and eventually process optimization. Previous modeling approaches fall short in addressing only specific conditions with limited capabilities of handling detailed morphology. For a comprehensive model, the necessary coupling of the structured and the property distributed character of the systems intrinsically leads to a multiscale, multivariate population balance modeling problem with many challenges. Such a modeling approach will not only reflect the new experimental opportunities that appeared in the recent years. Instead, a framework will be developed to support also future experimental efforts by introducing a generic morphology description.

丝状微生物广泛用于抗生素、有机酸和蛋白质的生物技术生产。众所周知，加工条件，特别是流体力学，影响微生物的形态。它们可能以自由分散的菌丝、絮状物/团块或颗粒的形式出现。反过来，形态强烈影响生产率，因此影响该方法的经济性。数学模型可以提供更好的理解和最终优化过程的手段。以前的建模方法在处理细节形态的能力有限的情况下，只解决特定的条件。对于一个综合的模型，必要的耦合的结构和属性的分布特性的系统本质上导致了一个多尺度，多变量的人口平衡建模问题，许多挑战。这种建模方法不仅反映了近年来出现的新的实验机会。相反，将开发一个框架，以支持未来的实验工作，通过引入一个通用的形态描述。