Identification of systems properties determining the dynamics of the hepatitis B virus infection cycle and cross-talk to host cell responses (10)

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The dynamics of the cross-talk of the HBV infection cycle with host cell responses is studied by quantitative mass spectrometry. Based on this data a mathematical model of the HBV infection cycle is calibrated and will be linked to a dynamic pathway model of interferon (IFN)α induced antiviral responses. The aim is to identify mechanisms responsible for the synergistic effects of Myrcludex B (MyrB) and pegylated IFNα (PEG-IFNα) that was observed in clinical trials and thereby provide means to identify patients that might particularly benefit from the co-treatment of MyrB and PEG-IFNα.