Novel principles in bacterial central carbon metabolism: Linking environmental signals and metabolic responses in alphaproteobacteria (D02*)

细菌中心碳代谢的新原理：将α变形菌中的环境信号和代谢反应联系起来（D02*）

• 批准号: 317899516
• 金额: --
• 依托单位: Abteilung Biochemie und Synthetischer Metabolismus
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/317899516?language=en
• 关键词: Novel; principles; bacterial; central; carbon

To achieve optimal growth, organisms need to tightly balance the distribution of carbon between energy conservation and biomass formation in response to a changing environment. So far this process has been mainly studied in Escherichia coli, but evidence accumulated that other bacteria follow different strategies. Here, we will characterize the metabolic and regulatory diversity of central carbon metabolism in the environmentally abundant group of alphaproteobacteria. We will identify environmental factors and signals that control carbon assimilation and study the dynamic res¬ponse of central carbon metabolism of Alphaproteobacteria upon external perturbation.

为了实现最佳生长，生物体需要在能量保存和生物量形成之间紧密平衡碳分布，以应对不断变化的环境。到目前为止，这一过程主要在大肠杆菌中进行研究，但越来越多的证据表明，其他细菌也遵循不同的策略。在这里，我们将描述环境丰富的α变形菌群中中心碳代谢的代谢和调节多样性。我们将识别控制碳同化的环境因素和信号，并研究α变形菌在外部扰动下中枢碳代谢的动态响应。