Regulation of motility by the stringent response in B. subtilis (E06*)

枯草芽孢杆菌 (E06*) 中严格反应对运动性的调节

• 批准号: 317949536
• 金额: --
• 依托单位: Zentrum für Synthetische Mikrobiologie (SYNMIKRO)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/317949536?language=en
• 关键词: Regulation; motility; stringent; response; B.

The alarmones (p)ppGpp play crucial roles in the environmental signal response of bacteria (stringent response). The bifunctional RelA/SpoT proteins are conserved in bacteria and mediate their synthesis and degradation. In the Firmicutes, two additional small alarmone synthetases (SAS1/2) are present. While their biochemical/structural features are well understood, their role within the cellular response to environmental signals lags behind. We will define the roles of SAS1/SAS2 within the cellular signaling network of B. subtilis and unravel the role of their (p)ppGpp product for motility regulation and response to zinc stress.

丙二醛(P)ppGpp在细菌的环境信号反应(严格反应)中起着至关重要的作用。双功能的RelA/Spot蛋白在细菌中是保守的，并调节它们的合成和降解。在Firmicuts中，还存在另外两个小丙酮合成酶(SAS1/2)。虽然它们的生化/结构特征已被很好地理解，但它们在细胞对环境信号的反应中的作用滞后。我们将确定SAS1/SAS2在枯草杆菌细胞信号网络中的作用，并揭示它们的(P)ppGpp产物在运动调节和对锌胁迫反应中的作用。