Mechanisms of sensing and response to environmental cues by fungal cell wall components (E09*)

真菌细胞壁成分对环境信号的感知和响应机制（E09*）

• 批准号: 317950955
• 金额: --
• 依托单位: Arbeitsgruppe Strukturbiochemie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/317950955?language=en
• 关键词: Mechanisms; sensing; response; environmental; cues

In this project our group focuses on the structural biology of fungal cell walls and their components. After having studied the structural repertoire and specificity of fungal adhesins we will now combine biochemical, structural and functional approaches for studying cell wall-anchored proteins, which are crucial for cell wall cross-linking, integrity and remodelling. By advancing our understanding of the complex ultrastructure of fungal cell walls we will provide structural cues for the development and optimization of fungicides.

在这个项目中，我们的团队专注于真菌细胞壁及其组件的结构生物学。在研究了真菌粘附素的结构库和特异性之后，我们现在将联合收割机结合生物化学、结构和功能方法来研究细胞壁锚定蛋白，这对于细胞壁交联、完整性和重塑至关重要。通过推进我们对真菌细胞壁复杂超微结构的理解，我们将为杀菌剂的开发和优化提供结构线索。