Mechanism elucidation and drug development of early-stage FOP respond to TGF-b signaling using patient-derived iPSCs

使用患者来源的 iPSC 阐明早期 FOP 对 TGF-b 信号传导的反应机制并进行药物开发

• 批准号: 19K16540
• 负责人: Zhao Chengzhu
• 金额: $ 2.66万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K16540/
• 关键词: 進行性骨化性線維異形成症; FOP; iPS細胞; iPS 細胞; フレア・アップ; 間葉系幹細胞

项目成果

Suppression of Heterotopic Ossification in Fibrodysplasia Ossificans Progressiva Models by an mTOR Signaling Modulator

mTOR 信号调节剂抑制进行性骨化性纤维发育不良模型中的异位骨化

• 发表时间: 2019
• 作者: Chengzhu Zhao

In vivo regeneration of rat laryngeal cartilage with mesenchymal stem cells derived from human induced pluripotent stem cells via neural crest cells

人诱导多能干细胞来源的间充质干细胞通过神经嵴细胞体内再生大鼠喉软骨

• DOI: 10.1016/j.scr.2021.102233
• 发表时间: 2021
• 期刊: Stem Cell Research
• 影响因子: 1.2
• 作者: Masayoshi Yoshimatsu;Hiroe Ohnishi;Chengzhu Zhao;Yasuyuki Hayashi;Fumihiko Kuwata;Shinji Kaba;Hideaki Okuyama;Yoshitaka Kawai;Nao Hiwatashi;Yo Kishimoto;Tatsunori Sakamoto;Makoto Ikeya;Koichi Omori
• 通讯作者: Koichi Omori

ヒトiPS細胞由来間葉系幹細胞で作製した神経導管による末梢神経の再生に成功

使用由人 iPS 细胞衍生的间充质干细胞制成的神经导管成功再生周围神经

Pro-angiogenic scaffold-free Bio three-dimensional conduit developed from human induced pluripotent stem cell-derived mesenchymal stem cells promotes peripheral nerve regeneration

• DOI: 10.1038/s41598-020-68745-1
• 发表时间: 2020-07-21
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Mitsuzawa, Sadaki;Zhao, Chengzhu;Ikeya, Makoto
• 通讯作者: Ikeya, Makoto

Indirect mTOR Inhibition Attenuates Fibrodysplasia Ossificans Progressiva (FOP) Identified by Using Patient-Derived iPSCs

间接 mTOR 抑制可减轻使用患者来源的 iPSC 鉴定的进行性骨化性纤维发育不良 (FOP)

• 发表时间: 2019
• 作者: Yoshiyuki Saito;Hiroshi Takami;Kaori Kameyama;Hirofumi Ikeda; Shinya Uchino;Koichi Ito;Hirofumi Kawakubo;Yuko Kitagawa; Hideyuki Saya;Osamu Nagano;Chengzhu Zhao
• 通讯作者: Chengzhu Zhao