Iron-Based CO Releasing Molecules (CORMs) with multidentate organic amides

具有多齿有机酰胺的铁基 CO 释放分子 (CORM)

• 批准号: 319916811
• 负责人: Professor Dr. Matthias Westerhausen
• 金额: --
• 依托单位: Lehrstuhl für Anorganische Chemie I
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/319916811?language=en
• 关键词: Iron; Based; CO; Releasing; Molecules

Carbon monoxide (CO) represents an important signaling molecule. Due to the extreme toxicity of gaseous CO if inhaled sophisticated strategies have to be developed in order to use this gaseous messenger molecule in cellular tissues. The most promising strategies include the use of carbonyl complexes of transition metals (CO-releasing molecules, CORMs). In this project we aim to synthesize optimized CO complexes that release carbon monoxide upon induction (e.g. irradiation with visible light) at the predetermined disease site. Certain requirements have to be fulfilled by these CO-releasing molecules (CORMs) such as water solubility, triggered CO release, and non-toxicity of the complexes as well as their degradation products. In order to study the CO release mechanism, iron complexes with different polyamide ligand environments and varying carbonyl content will be prepared. Photosensitization of iron carbonyl complexes to visible light and CO release kinetics will be studied. Therefore our research will focus on iron carbonyl complexes, NMR spectroscopy will be used in order to investigate the mechanisms of CO liberation. Kinetic measurements will be performed using IR, Raman, and UV/Vis spectroscopic methods.

一氧化碳（CO）代表一个重要的信号分子。由于气体CO的极端毒性，如果必须开发吸入的复杂策略才能在细胞组织中使用这种气态的允许分子。最有希望的策略包括使用过渡金属的羰基复合物（共同释放分子，Corms）。在该项目中，我们旨在合成优化的CO络合物，该复合物在预定的疾病部位释放一氧化碳（例如用可见光照射）释放一氧化碳。这些共同释放的分子（CORM）必须满足某些要求，例如水溶性，触发的CO释放以及复合物的无毒性及其降解产物。为了研究CO释放机制，将准备具有不同聚酰胺配体环境和不同羰基含量的铁络合物。将研究铁羰基复合物对可见光和CO释放动力学的光敏化。因此，我们的研究将重点放在铁羰基复合物上，NMR光谱将用于研究CO解放的机制。动力学测量将使用IR，拉曼和紫外线/VIS光谱方法进行。