Iron-Based CO Releasing Molecules (CORMs) with multidentate organic amides

具有多齿有机酰胺的铁基 CO 释放分子 (CORM)

• 批准号: 319916811
• 负责人: Professor Dr. Matthias Westerhausen
• 金额: --
• 依托单位: Lehrstuhl für Anorganische Chemie I
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/319916811?language=en
• 关键词: Iron; Based; CO; Releasing; Molecules

Carbon monoxide (CO) represents an important signaling molecule. Due to the extreme toxicity of gaseous CO if inhaled sophisticated strategies have to be developed in order to use this gaseous messenger molecule in cellular tissues. The most promising strategies include the use of carbonyl complexes of transition metals (CO-releasing molecules, CORMs). In this project we aim to synthesize optimized CO complexes that release carbon monoxide upon induction (e.g. irradiation with visible light) at the predetermined disease site. Certain requirements have to be fulfilled by these CO-releasing molecules (CORMs) such as water solubility, triggered CO release, and non-toxicity of the complexes as well as their degradation products. In order to study the CO release mechanism, iron complexes with different polyamide ligand environments and varying carbonyl content will be prepared. Photosensitization of iron carbonyl complexes to visible light and CO release kinetics will be studied. Therefore our research will focus on iron carbonyl complexes, NMR spectroscopy will be used in order to investigate the mechanisms of CO liberation. Kinetic measurements will be performed using IR, Raman, and UV/Vis spectroscopic methods.

一氧化碳（CO）是一种重要的信号分子。由于吸入气态CO的极端毒性，必须开发复杂的策略以在细胞组织中使用这种气态信使分子。最有前途的策略包括使用过渡金属的羰基络合物（CO释放分子，CORM）。在这个项目中，我们的目标是合成优化的CO复合物，在预定的疾病部位诱导（例如，用可见光照射）后释放一氧化碳。这些CO释放分子（CORM）必须满足某些要求，例如水溶性、触发的CO释放和复合物及其降解产物的无毒性。为了研究CO释放机理，将制备具有不同聚酰胺配体环境和不同羰基含量的铁络合物。本文研究了羰基铁配合物的可见光光敏化作用和CO释放动力学。因此，我们的研究将集中在铁羰基配合物，核磁共振光谱将被用来研究CO的释放机制。将使用IR、拉曼和UV/维斯光谱法进行动力学测量。