Iron-Based CO Releasing Molecules (CORMs) with multidentate organic amides

一氧化碳是一种重要的信号分子。由于吸入气态CO的极端毒性，必须开发复杂的策略，以便在细胞组织中使用这种气态信使分子。最有希望的策略包括使用过渡金属的羰基配合物（co释放分子，CORMs）。在这个项目中，我们的目标是合成优化的CO配合物，在预定的疾病部位诱导（例如用可见光照射）释放一氧化碳。这些CO释放分子（corm）必须满足一定的要求，如水溶性、触发的CO释放、配合物及其降解产物的无毒性。为了研究CO的释放机理，制备了不同聚酰胺配体环境和不同羰基含量的铁配合物。羰基铁配合物对可见光的光敏化和CO释放动力学将被研究。因此，我们的研究将集中在铁羰基配合物上，核磁共振波谱将用于研究CO释放的机制。动力学测量将使用红外、拉曼和紫外/可见光谱方法进行。

Carbon monoxide (CO) represents an important signaling molecule. Due to the extreme toxicity of gaseous CO if inhaled sophisticated strategies have to be developed in order to use this gaseous messenger molecule in cellular tissues. The most promising strategies include the use of carbonyl complexes of transition metals (CO-releasing molecules, CORMs). In this project we aim to synthesize optimized CO complexes that release carbon monoxide upon induction (e.g. irradiation with visible light) at the predetermined disease site. Certain requirements have to be fulfilled by these CO-releasing molecules (CORMs) such as water solubility, triggered CO release, and non-toxicity of the complexes as well as their degradation products. In order to study the CO release mechanism, iron complexes with different polyamide ligand environments and varying carbonyl content will be prepared. Photosensitization of iron carbonyl complexes to visible light and CO release kinetics will be studied. Therefore our research will focus on iron carbonyl complexes, NMR spectroscopy will be used in order to investigate the mechanisms of CO liberation. Kinetic measurements will be performed using IR, Raman, and UV/Vis spectroscopic methods.