Gestational hypertension and diabetes associated birth outcome, and constant postpartum non-communicable disease risks

妊娠高血压和糖尿病相关的出生结果以及持续的产后非传染性疾病风险

基本信息

  • 批准号:
    19K24191
  • 负责人:
  • 金额:
    $ 1.83万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Research Activity Start-up
  • 财政年份:
    2019
  • 资助国家:
    日本
  • 起止时间:
    2019-08-30 至 2024-03-31
  • 项目状态:
    已结题

项目摘要

The study aimed to identify non-communicable disease (NCD) risks among women from Pregnancy to postpartum in the resource-limited populations in Bangladesh. This study is part of an observational pregnancy cohort conducted in Bangladesh, over 1 consecutive year. 387 women were recruited within 24-36 weeks of pregnancy, and 364 women were followed over at 6 months post-pregnancy. Data on blood pressure, blood glucose and/or glycosylated hemoglobin, and hemoglobin level were collected during pregnancy and after 6 months of post-pregnancy. The pregnant women's mean (sd) age was 24.4 (5.0) years. Ninety-three percent of women gave live birth. Overall, 18.9% (n=71/376) of women at the base were at NCDs risk, but this risk was elevated at follow-up to 55.5% (n=196/353). At baseline, the incidence of pregnancy-induced hypertension (PIH) (SBP >140 mmHg & DBP >90 mmHg) was 8.8%, and elevated PIH (SBP >130-139 mmHg & DBP >80-89 mmHg) was 28.5%. At post-pregnancy follow-up, the incidence of elevated high blood pressure (HBP) was 12.8% and 3.05% had HBP. At baseline, the prevalence of gestational diabetes was 4.5% (HbA1c>6.4%) and glycemic intolerance (GI) 40.6% (HbA1C=5.4%-6.4%) using WHO criteria. At follow-up, the diabetic prevalence was 11% and GI was 46% (HbA1C=5.7%-6.4%). Five women died due to birth complications i.e. excessive bleeding or prolonged labor. The study findings advocate appropriate implementation programs for NCDs that linger from pregnancy in resource-limited contexts.
该研究旨在确定孟加拉国资源有限人口中从怀孕到产后妇女的非传染性疾病(NCD)风险。本研究是在孟加拉国连续1年进行的观察性妊娠队列的一部分。在怀孕24-36周内招募了387名妇女,并在怀孕后6个月对364名妇女进行了随访。在妊娠期间和妊娠后6个月收集血压、血糖和/或糖化血红蛋白以及血红蛋白水平的数据。孕妇的平均(sd)年龄为24.4(5.0)岁。93%的妇女活产。总体而言,在基础研究中,18.9%(n=71/376)的女性有非传染性疾病的风险,但在随访时,这一风险升高至55.5%(n=196/353)。基线时,妊娠高血压(SBP >140 mmHg & DBP >90 mmHg)的发生率为8.8%,妊高征(SBP >130-139 mmHg & DBP >80-89 mmHg)的发生率为28.5%。在妊娠后随访时,高血压(HBP)的发生率为12.8%,3.05%的HBP。基线时,根据WHO标准,妊娠期糖尿病患病率为4.5%(HbA 1c>6.4%),血糖不耐受(GI)为40.6%(HbA 1C =5.4%-6.4%)。随访时,糖尿病患病率为11%,GI为46%(HbA 1C =5.7%-6.4%)。5名妇女死于分娩并发症,即出血过多或分娩时间过长。研究结果提倡在资源有限的情况下,对从怀孕开始就存在的非传染性疾病实施适当的方案。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Incidence of Diabetes and Hypertension among postpartum Women in Bangladesh
孟加拉国产后妇女糖尿病和高血压的发病率
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Nishimura Takaaki;Miyachi Ryo;寺岡睦;Farzana Ferdous
  • 通讯作者:
    Farzana Ferdous
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