Nonpersistent chemical exposure, placental development, and maternal pre- and post-pregnancy cardiovascular health

非持续性化学品接触、胎盘发育和孕产妇孕前和孕后心血管健康

• 批准号: 10533382
• 负责人: Linda G Kahn
• 金额: $ 24.88万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10533382
• 关键词: Affect; Age; Angiogenesis Inhibitors; Angiogenic Factor; Attention; Award; Biological; Biological Markers; Birth; Birth Weight; Blood Pressure; Blood Vessels; Blood flow; Body fat; Body mass index; Cardiac Output; Cardiovascular Diagnostic Techniques; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Cause of Death; Chemical Exposure; Chemicals; Child; Child Health; Chronic; Clinical; Complex; Conceptions; Data; Diabetes Mellitus; Diethylhexyl Phthalate; Eclampsia; Education; Educational workshop; Endocrine Disruptors; Endothelium; Environment; Environmental Epidemiology; Epidemiologist; Exposure to; Faculty; Fertility; Fetal Development; Functional disorder; Funding; Goals; Growth; Growth and Development function; Health; Hospitalization; Hypertension; Impairment; Incidence; Inflammatory; Link; Lipids; Long-Term Effects; Maternal Exposure; Maternal and Child Health; Measurable; Measures; Mentorship; Methodology; Mothers; Neonatal Mortality; New York; Nulliparity; Nutrient; Organ; Outcome; PGF gene; Participant; Pathway interactions; Perfusion; Phase; Physiologic pulse; Placenta; Placentation; Plastics; Population; Positioning Attribute; Postpartum Period; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Trimesters; Principal Investigator; Publishing; Questionnaires; Research; Research Activity; Research Personnel; Research Project Grants; Risk; Risk Factors; Seminal fluid; Serum; Statistical Methods; Training; Training Activity; United States; Universities; Vascular Endothelial Growth Factor Receptor-1; Vascularization; Weight; Woman; Women' s Health; Work; advanced maternal age; adverse birth outcomes; apprenticeship; bisphenol A; blood pressure elevation; cardiovascular effects; cardiovascular health; cardiovascular risk factor; career; cohort; cytokine; design; early pregnancy; environmental chemical; experience; fetal; follow-up; longitudinal analysis; maternal serum; neonatal morbidity; personal care products; phthalates; post pregnancy; post-doctoral training; postnatal; pregnancy disorder; pregnancy hypertension; prenatal; prepregnancy; recruit; reproductive; reproductive epidemiology; reproductive success; skills; time-to-pregnancy; urinary

PROJECT SUMMARY/ABSTRACT In the United States, increasing numbers of women are experiencing pregnancy complications such as preeclampsia, eclampsia, and gestational hypertension that can put their own and their children’s immediate and long-term health at risk. In particular, these hypertensive disorders of pregnancy are associated with increased incidence of postnatal cardiovascular disease in women. The link appears to be the placenta, an organ that both regulates nutrient flow to the developing fetus and influences maternal cardiovascular function. Nonpersistent endocrine disrupting chemicals (EDCs), including bisphenols found in plastics and phthalates found in personal care products, have been associated with cardiovascular disease and may also be associated with placental dysfunction. Over the course of my masters, doctoral, and postdoctoral training, I have begun to develop a portfolio of published research in both environmental and reproductive epidemiology, with a particular emphasis on identifying underlying biological mechanisms. My prior education and experience positions me well to undertake my proposed K99/R00 research project: examining relations among maternal exposure to nonpersistent EDCs, biomarkers of placental dysfunction, and indicators of maternal cardiovascular disease both before and after pregnancy. This Pathway to Independence Award will provide the additional mentorship and expertise I need to transition to faculty and successfully compete for funding as a principal investigator. My training plan includes formal courses, workshops and seminars, directed readings, and apprenticeships to develop skills in 1) EDCs, environmental epidemiology, and exposure assessment, 2) advanced statistical methods, and 3) the intersection between placental and cardiovascular health. In the K99 phase of my research, I will leverage data currently being collected in the New York University (NYU) Children’s Health and Environment Study (CHES) that includes both prenatal maternal biomarker and questionnaire data as well as postnatal maternal cardiovascular measures. In the R00 phase, I will incorporate additional preconception data from the NYU Factors Influencing Reproductive Success and Time to Pregnancy (FIRST) Study. Specific Aims include 1) examining relations of maternal prenatal urinary phthalate and bisphenol levels to maternal biomarkers of placental development, and trimester-specific effects of EDCs on placental size at birth, 2) examining relations of prenatal urinary phthalate and bisphenol levels measured in three trimesters of pregnancy to maternal clinical cardiovascular risk factors at 1 and 2 years postpartum in CHES, and 3) assessing relations among maternal preconception phthalate and bisphenol exposure, preconception cardiovascular risk factors, time to pregnancy, and placental growth and development using combined CHES and FIRST data. These training and research activities will increase my expertise as an environmental epidemiologist and prepare me to successfully compete for R01 funding as an independent investigator with a focus on reproductive and women’s health.

项目概要/摘要 在美国，越来越多的女性正在经历妊娠并发症，例如 先兆子痫、子痫和妊娠高血压，可以让自己和孩子立即 和长期健康受到威胁。特别是，这些妊娠期高血压疾病与 女性产后心血管疾病的发病率增加。这个链接似乎是胎盘， 调节流向发育中胎儿的营养并影响母体心血管功能的器官。 非持久性内分泌干扰化学品 (EDC)，包括塑料中的双酚和邻苯二甲酸盐 存在于个人护理产品中，与心血管疾病有关，也可能与 与胎盘功能障碍有关。在我的硕士、博士和博士后培训过程中，我 已经开始开发一系列环境和生殖流行病学方面已发表的研究成果， 特别强调确定潜在的生物机制。我之前的教育和经验 使我能够很好地开展我提议的 K99/R00 研究项目：检查母亲之间的关系 暴露于非持久性 EDC、胎盘功能障碍的生物标志物和母体指标 怀孕前和怀孕后的心血管疾病。该独立之路奖将提供 我需要额外的指导和专业知识才能过渡到教师并成功竞争资助 首席研究员。我的培训计划包括正式课程、讲习班和研讨会、定向阅读、 和学徒培训，以培养以下方面的技能：1) EDC、环境流行病学和暴露评估，2) 先进的统计方法，3) 胎盘和心血管健康之间的交叉点。在K99中 在我的研究阶段，我将利用纽约大学 (NYU) 目前收集的数据 儿童健康与环境研究 (CHES)，包括产前母亲生物标志物和 问卷数据以及产后母亲心血管测量。在R00阶段，我将合并 来自纽约大学影响生殖成功和怀孕时间的因素的其他先入为主数据 （第一）学习。具体目标包括 1) 检查母亲产前尿邻苯二甲酸盐与 双酚水平对胎盘发育的母体生物标志物的影响，以及 EDC 对妊娠期的特异性影响 出生时胎盘大小，2) 检查产前尿液中邻苯二甲酸盐和双酚水平的关系 妊娠三个月对产后 1 年和 2 年母亲临床心血管危险因素的影响 CHES，以及 3) 评估母亲孕前邻苯二甲酸盐和双酚暴露之间的关系， 孕前心血管危险因素、怀孕时间以及胎盘生长和发育 合并 CHES 和 FIRST 数据。这些培训和研究活动将增加我作为一名 环境流行病学家，帮助我作为独立人士成功竞争 R01 资金 专注于生殖和妇女健康的研究者。