Nonpersistent chemical exposure, placental development, and maternal pre- and post-pregnancy cardiovascular health

非持续性化学品接触、胎盘发育和孕产妇孕前和孕后心血管健康

• 批准号: 10533382
• 负责人: Linda G Kahn
• 金额: $ 24.88万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10533382
• 关键词: Affect; Age; Angiogenesis Inhibitors; Angiogenic Factor; Attention; Award; Biological; Biological Markers; Birth; Birth Weight; Blood Pressure; Blood Vessels; Blood flow; Body fat; Body mass index; Cardiac Output; Cardiovascular Diagnostic Techniques; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Cause of Death; Chemical Exposure; Chemicals; Child; Child Health; Chronic; Clinical; Complex; Conceptions; Data; Diabetes Mellitus; Diethylhexyl Phthalate; Eclampsia; Education; Educational workshop; Endocrine Disruptors; Endothelium; Environment; Environmental Epidemiology; Epidemiologist; Exposure to; Faculty; Fertility; Fetal Development; Functional disorder; Funding; Goals; Growth; Growth and Development function; Health; Hospitalization; Hypertension; Impairment; Incidence; Inflammatory; Link; Lipids; Long-Term Effects; Maternal Exposure; Maternal and Child Health; Measurable; Measures; Mentorship; Methodology; Mothers; Neonatal Mortality; New York; Nulliparity; Nutrient; Organ; Outcome; PGF gene; Participant; Pathway interactions; Perfusion; Phase; Physiologic pulse; Placenta; Placentation; Plastics; Population; Positioning Attribute; Postpartum Period; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Trimesters; Principal Investigator; Publishing; Questionnaires; Research; Research Activity; Research Personnel; Research Project Grants; Risk; Risk Factors; Seminal fluid; Serum; Statistical Methods; Training; Training Activity; United States; Universities; Vascular Endothelial Growth Factor Receptor-1; Vascularization; Weight; Woman; Women' s Health; Work; advanced maternal age; adverse birth outcomes; apprenticeship; bisphenol A; blood pressure elevation; cardiovascular effects; cardiovascular health; cardiovascular risk factor; career; cohort; cytokine; design; early pregnancy; environmental chemical; experience; fetal; follow-up; longitudinal analysis; maternal serum; neonatal morbidity; personal care products; phthalates; post pregnancy; post-doctoral training; postnatal; pregnancy disorder; pregnancy hypertension; prenatal; prepregnancy; recruit; reproductive; reproductive epidemiology; reproductive success; skills; time-to-pregnancy; urinary

PROJECT SUMMARY/ABSTRACT In the United States, increasing numbers of women are experiencing pregnancy complications such as preeclampsia, eclampsia, and gestational hypertension that can put their own and their children’s immediate and long-term health at risk. In particular, these hypertensive disorders of pregnancy are associated with increased incidence of postnatal cardiovascular disease in women. The link appears to be the placenta, an organ that both regulates nutrient flow to the developing fetus and influences maternal cardiovascular function. Nonpersistent endocrine disrupting chemicals (EDCs), including bisphenols found in plastics and phthalates found in personal care products, have been associated with cardiovascular disease and may also be associated with placental dysfunction. Over the course of my masters, doctoral, and postdoctoral training, I have begun to develop a portfolio of published research in both environmental and reproductive epidemiology, with a particular emphasis on identifying underlying biological mechanisms. My prior education and experience positions me well to undertake my proposed K99/R00 research project: examining relations among maternal exposure to nonpersistent EDCs, biomarkers of placental dysfunction, and indicators of maternal cardiovascular disease both before and after pregnancy. This Pathway to Independence Award will provide the additional mentorship and expertise I need to transition to faculty and successfully compete for funding as a principal investigator. My training plan includes formal courses, workshops and seminars, directed readings, and apprenticeships to develop skills in 1) EDCs, environmental epidemiology, and exposure assessment, 2) advanced statistical methods, and 3) the intersection between placental and cardiovascular health. In the K99 phase of my research, I will leverage data currently being collected in the New York University (NYU) Children’s Health and Environment Study (CHES) that includes both prenatal maternal biomarker and questionnaire data as well as postnatal maternal cardiovascular measures. In the R00 phase, I will incorporate additional preconception data from the NYU Factors Influencing Reproductive Success and Time to Pregnancy (FIRST) Study. Specific Aims include 1) examining relations of maternal prenatal urinary phthalate and bisphenol levels to maternal biomarkers of placental development, and trimester-specific effects of EDCs on placental size at birth, 2) examining relations of prenatal urinary phthalate and bisphenol levels measured in three trimesters of pregnancy to maternal clinical cardiovascular risk factors at 1 and 2 years postpartum in CHES, and 3) assessing relations among maternal preconception phthalate and bisphenol exposure, preconception cardiovascular risk factors, time to pregnancy, and placental growth and development using combined CHES and FIRST data. These training and research activities will increase my expertise as an environmental epidemiologist and prepare me to successfully compete for R01 funding as an independent investigator with a focus on reproductive and women’s health.

项目摘要/摘要 在美国，越来越多的妇女正在经历怀孕并发症，例如 先兆子痫，eClampsia和妊娠高血压，可以使自己的孩子立即使用 和长期健康处于危险之中。特别是，这些高血压疾病与 女性出生后心血管疾病的进攻增加。该链接似乎是placeta，一个 器官都调节营养流向发育中的胎儿，并影响母校心血管功能。 非或非内分泌破坏化学物质（EDC），包括塑料和邻苯二甲酸盐中的双酚 在个人护理产品中发现，与心血管疾病有关，也可能是 与胎盘功能障碍相关。在我的硕士学位，博士和博士后培训的过程中，我 已经开始开发一项在环境和生殖流行病学方面发表的研究组合， 特别强调识别潜在的生物学机制。我先前的教育和经验 我的位置很好地进行了我提出的K99/R00研究项目：检查母亲之间的关系 暴露于非持久性EDC，胎盘功能障碍的生物标志物和母体指标 怀孕前后的心血管疾病。这一获得独立奖的途径将提供 我需要过渡到教师，并成功地争夺资金 首席研究员。我的培训计划包括正式课程，讲习班和半小伙 以及在1）EDC，环境流行病学和暴露评估中发展技能的学徒制，2） 晚期统计方法，以及3）位置和心血管健康之间的相交。在K99中 我的研究阶段，我将利用目前正在纽约大学（NYU）收集的数据 儿童健康与环境研究（CHES）包括产前生物标志物和 问卷数据以及产后母体心血管措施。在R00阶段，我将合并 来自纽约大学因素的其他先选数据影响了生殖成功和妊娠时间 （第一）研究。具体目的包括1）检查孕产妇尿邻苯二甲酸酯和 双苯酚水平达到了占地开发的主要生物标志物，EDC对孕妇的特异性影响 出生时的胎盘大小，2）检查在以 产后1和2年的三个怀孕三个怀孕的怀孕临床心血管危险因素 CHE和3）评估邻苯二甲酸盐和双酚暴露之间的关系， 先入为主的心血管危险因素，怀孕时间以及使用占地的生长和发育 CHE和第一个数据组合。这些培训和研究活动将增加我作为一个专业知识 环境流行病学家，并为我准备成功竞争R01的资金 研究人员专注于复制和妇女健康。