International study to establish a new prion identified with fatal familial or sporadic insomnia.

国际研究确定了一种新的朊病毒，该病毒可导致致命的家族性或散发性失眠。

• 批准号: 19KK0213
• 负责人: KITAMOTO Tetsuyuki
• 金额: $ 11.81万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-10-07 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19KK0213/
• 关键词: fatal familial insomnia; thalamic form; M2C(sv) prion; M2C(lv) prion; プリオン; FFI; SFI; 新しいプリオン分類; ＦＦＩ; ＳＦＩ

项目成果

Potential for transmission of sporadic Creutzfeldt-Jakob disease through peripheral routes

• DOI: 10.1038/s41374-021-00641-2
• 发表时间: 2021-07-12
• 期刊: LABORATORY INVESTIGATION
• 影响因子: 5
• 作者: Kobayashi, Atsushi;Munesue, Yoshiko;Kitamoto, Tetsuyuki
• 通讯作者: Kitamoto, Tetsuyuki

Ganglioside Synthase Knockout Reduces Prion Disease Incubation Time in Mouse Models

神经节苷脂合酶敲除可缩短小鼠模型中朊病毒病的潜伏时间

• DOI: 10.1016/j.ajpath.2018.11.009
• 发表时间: 2019
• 期刊: The American Journal of Pathology
• 作者: Kobayashi Atsushi;Qi Zechen;Shimazaki Taishi;Munesue Yoshiko;Miyamoto Tomomi;Isoda Norikazu;Sawa Hirofumi;Aoshima Keisuke;Kimura Takashi;Mohri Shirou;Kitamoto Tetsuyuki;Yamashita Tadashi;Miyoshi Ichiro
• 通讯作者: Miyoshi Ichiro

Clinicopathological findings of an MM2-cortical-type sporadic Creutzfeldt-Jakob disease patient with cortical blindness during a course of glaucoma and age-related macular degeneration

• DOI: 10.1080/19336896.2019.1631680
• 发表时间: 2019-01-01
• 期刊: PRION
• 影响因子: 2.3
• 作者: Hayashi, Yuichi;Iwasaki, Yasushi;Shimohata, Takayoshi
• 通讯作者: Shimohata, Takayoshi

Autopsied case of sporadic Creutzfeldt-Jakob disease pathologically classified as MM1+2C-type

散发性克雅氏病尸检一例，病理学分类为MM1 2C型

• DOI: 10.1111/neup.12557
• 发表时间: 2019
• 期刊: Neuropathology
• 影响因子: 2.3
• 作者: Iwasaki Y;Kato H;Ando T;Akagi A;Mimuro M;Miyahara H;Kobayashi A;Kitamoto T;Yoshida M.
• 通讯作者: Yoshida M.

Correction to: In Vitro Seeding Activity of Glycoform-Deficient Prions from Variably Protease-Sensitive Prionopathy and Familial CJD Associated with PrPV180I Mutation

修正：来自不同蛋白酶敏感性朊病毒病和与 PrPV180I 突变相关的家族性克雅氏病的糖型缺陷型朊病毒的体外播种活性

• DOI: 10.1007/s12035-019-1508-3
• 发表时间: 2019
• 期刊: Mol Neurobiol
• 影响因子: 5.1
• 作者: Wang Z;Yuan J;Shen P;Abskharon R;Lang Y;Dang J;Adornato A;Xu L;Chen J;Feng J;Moudjou M;Kitamoto T;Lee HG;Kim YS;Langeveld J;Appleby B;Ma J;Kong Q;Petersen RB;Zou WQ;Cui L
• 通讯作者: Cui L