To study the molecular mechanism of prion protein conversion

实验结果表明，在高表达鼠朊蛋白（PrP）的动物模型中，朊蛋白病的临床表现为脑内出现海绵状改变和PrP异常聚集。因此，该转基因小鼠有可能作为自发性朊病毒病的动物模型。我们检查了野生小鼠和具有库田鼠PrP（Ki-Bank）的基因敲入小鼠的传播研究。因此，很明显，在该转基因模型中PrP转化是不完美的。然而，这是出来，这个Ki银行是一个有用的动物模型的实验transmission。

Overexpression model for Bank vole prion protein (PrP) showed clinical signs of prion disease, spongiform changes and abnormal PrP accumulations in the brain. Therefore, this transgenic mice have a possibility as an animal model for spontaneous prion diseases. We examined the transmission studies with the wild mice and the knock-in mice having bank vole PrP (Ki-Bank) There were no successful transmissions from the transgenic mouse brains. Therefore, it is clear that the PrP conversion is imperfect in this transgenic model. However, it is coming out that this Ki-Bank is a useful animal model for the experimentaltransmission.