new classification of sporadic CJD with MV2.

散发性克雅氏病 MV2 的新分类。

• 批准号: 24650185
• 负责人: KITAMOTO Tetsuyuki
• 金额: $ 2.5万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24650185/
• 关键词: ﾌﾟﾘｵﾝ; MV2; 感染性; ﾉｯｸｲﾝﾏｳｽ; 新分類; プリオン; クロイツフェルト・ヤコブ病; 孤発性; 感染実験; ウエスタンブロット; ノックインマウス

There are MV2 cases in sporadic Creuzfeldt-Jakob disease. We established the method to classify these MV2 cases into cases with V2 prions or M2 prions. In Western blot analysis, T-1 antibody revealed Mi PrPres molecule in cases with V2 prions, while this antibody did not detected in cases with M2 prions. In cases with V2 prions, the infectivity shows the similar pattern with VV2 prions. Therefore, we established the practical classification method of MV2 prions.

散发性克雅氏病中有MV2病例。我们建立了将这些MV2病例分为V2型和M2型的方法。Western blot分析，T-1抗体在V2型朊病毒中检测到Mi PrPres分子，而在M2型朊病毒中未检测到该抗体。在感染V2朊病毒的病例中，传染性表现出与VV2朊病毒相似的模式。因此，我们建立了实用的MV2朊病毒分类方法。

项目成果

Glycoform-selective prion formation in sporadic and familial forms of prion disease.

• DOI: 10.1371/journal.pone.0058786
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Xiao X;Yuan J;Haïk S;Cali I;Zhan Y;Moudjou M;Li B;Laplanche JL;Laude H;Langeveld J;Gambetti P;Kitamoto T;Kong Q;Brandel JP;Cobb BA;Petersen RB;Zou WQ
• 通讯作者: Zou WQ

Creutzfeldt-Jakob disease with the M232R mutation in the prion protein gene in two cases showing different disease courses: a clinicopathological study

朊病毒蛋白基因 M232R 突变的克雅氏病两例表现出不同的病程：临床病理学研究

• DOI: 10.1016/j.jns.2011.08.008
• 发表时间: 2012
• 期刊: Journal of the neurological Sciences
• 影响因子: 4.4
• 作者: Takeda N;Yokota O;Terada S;Haraguchi T;Nobukuni K;Mizuki R;Honda H;Yoshida H;Kishimoto Y;Oshima E;Ishizu H;Katsuya Satoh K;Kitamoto T;Ihara Y;Uchitomi Y.
• 通讯作者: Uchitomi Y.

Enhanced Antigen Retrieval of Amyloid β Immunohistochemistry: Re-evaluation of Amyloid β Pathology in Alzheimer Disease and Its Mouse Model

• DOI: 10.1369/0022155412456379
• 发表时间: 2012-10-01
• 期刊: JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
• 影响因子: 3.2
• 作者: Kai, Hideaki;Shin, Ryong-Woon;Kitamoto, Tetsuyuki
• 通讯作者: Kitamoto, Tetsuyuki

Insight into the frequent occurrence of dura mater graft-associated Creutzfeldt-Jakob disease in Japan

• DOI: 10.1136/jnnp-2012-304850
• 发表时间: 2013-10-01
• 期刊: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
• 影响因子: 11
• 作者: Hamaguchi, Tsuyoshi;Sakai, Kenji;Yamada, Masahito
• 通讯作者: Yamada, Masahito

Quantitative analysis of wet-heat inactivation in bovine spongiform encephalopathy

牛海绵状脑病湿热灭活的定量分析

• DOI: 10.1016/j.bbrc.2013.01.081
• 发表时间: 2013
• 期刊: Biochem Biophys Res Commun
• 作者: Matsuura Y;Ishikawa Y;Bo X;Murayama Y;Yokoyama T;Somerville RA;Kitamoto T;Mohri S.
• 通讯作者: Mohri S.