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Physical activity in patients with sickle cell disease: Effect on the vascular function, frequency of painful episodes and clinical course of the disease

镰状细胞病患者的体力活动：对血管功能、疼痛发作频率和疾病临床病程的影响

基本信息

批准号：
19KK0248
负责人：
tripette julien
金额：
$ 10.9万
依托单位：
Ochanomizu University
依托单位国家：
日本
项目类别：
Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
财政年份：
2019
资助国家：
日本
起止时间：
2019-10-07 至 2023-03-31
项目状态：
已结题

项目摘要

To date, clinical complications associated with sickle cell diseases (SCD) have never been studied relatively to the level of objectively measured physical activity (PA). By March 31, 2022, 85 subjects (65 patients and 20 healthy subjects) have been included in the study protocol. All subjects underwent a 5-week assessment of PA. The SCD patients have been submitted to a panel of tests aiming at assessing their clinical status and vascular health. They also completed a diary to record pain, potential vaso-occlusive painful events and related medications. Eighty-two subjects have completed the baseline assessment. Thirty patients have been included in a 3-month longitudinal protocol that includes a PA intervention and follow-up visits. Twenty-two of them have completed the whole longitudinal protocol. At baseline, the median daily step-count of patients are distributed from 3341 to 29643 steps. Some patients regularly performed more than 300 min per day of moderate-to-vigorous PA. Subjects with normal hemoglobin showed a similar range for step-count indicating that SCD patients can perform as much PA as their control counterpart. No relationship has been found between severe clinical events and the volume or intensity of PA. However, a significant negative correlation was found between daily step-count and pain occurrence in patients who did not report major clinical complications. In addition, we observed a negative correlation between the volume of PA and blood viscosity, which points to an improved hemorheological profile in the most active patients.

迄今为止，与镰状细胞病（SCD）相关的临床并发症从未与客观测量的身体活动（PA）水平进行过相对研究。截至2022年3月31日，85名受试者（65名患者和20名健康受试者）已纳入研究方案。所有受试者进行为期5周的PA评估。SCD患者已被提交给一个旨在评估其临床状况和血管健康的测试小组。他们还完成了一份日记，记录疼痛、潜在的血管闭塞性疼痛事件和相关药物。82名受试者完成了基线评估。30名患者被纳入了一个为期3个月的纵向方案，包括PA干预和随访。其中22人完成了整个纵向方案。基线时，患者每日步数中位数分布在3341 - 29643步之间。一些患者每天定期进行超过300分钟的中高强度PA。血红蛋白正常的受试者显示出相似的步数范围，这表明SCD患者可以执行与对照组相同的PA。没有发现严重的临床事件与PA的体积或强度之间的关系。然而，在没有报告主要临床并发症的患者中，发现每日步数与疼痛发生率之间存在显著的负相关。此外，我们观察到PA的体积和血液粘度之间呈负相关，这表明在最活跃的患者中血液流变学特征得到改善。