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Mobile Brain/Body Imaging of Spatial Navigation

空间导航的移动脑/身体成像

基本信息

批准号：
321967722
负责人：
Professor Dr. Klaus Gramann
金额：
--
依托单位：
Swartz Center for Computational Neuroscience
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2016
资助国家：
德国
起止时间：
2015-12-31 至 2019-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/321967722?language=en
关键词：
Mobile Brain Body Imaging Spatial

项目摘要

The goal of this proposal is to investigate the cortical dynamics that support spatial orienting during active human movement in space reflecting the integration of idiothetic information from the visual, the vestibular, and the kinesthetic system. This overall objective shall help to develop theories of spatial navigation and how different senses contribute to spatial orienting. Furthermore, the proposed experiments aim at modeling the brain dynamics accompanying visual and vestibular information on physical rotation and translation in space, and how these contribute to spatial updating. Finally, investigating the brain dynamics originating in or near the retrosplenial complex (RSC), a brain structure that is central to spatial orienting, will contribute to identifying potential different computational functions of this structure. To this end, we will compare active physical spatial orienting with visual flow orienting in a series of experiments. To record the human brain dynamics during mobile spatial orienting electroencephalography (EEG), full-body motion capture, and head mounted virtual reality will be synchronized. To image the recorded activity, data-driven analyses approaches will be used to investigate the interdependencies between human brain dynamics, physical movement, and cognitive processes. The last decade has brought recording technologies that allow a recording of EEG activity in mobile participants outside standard laboratory settings. Data-driven analyses approaches were developed that allow for separating brain and non-brain activities. Despite these developments, the standard approach to investigating human cognition requires participants to avoid movement and focuses on analyses at the sensor level. To further our understanding of the brain dynamics that accompany natural cognitive processes that are tight to and make use of our physical structure, we propose to image the brain dynamics during spatial orienting in actively moving participants. Imaging of brain dynamics has to provide information about when specific cortical structures demonstrate systematic changes in activity that can be linked to aspects of cognition and behavior. Electrophysiological data provide the temporal resolution necessary to deliver precise insights into the time course of information processing. The brain dynamics accompanying spatial orienting integrating movement-related idiothetic feedback are unknown. This proposal aims to overcome the existing limitations to brain imaging studies of spatial orienting by using mobile brain/body imaging. This will allow conclusions as to how the brain represents idiothetic information, how this information is used for spatial orienting, and how the brain dynamics of idiothetic information processing contribute to individual differences in spatial tasks.

本研究的目的是研究人类在空间活动中支持空间定向的皮质动力学，这反映了来自视觉、前庭和动觉系统的独特信息的整合。这一总体目标将有助于发展空间导航理论，以及不同的感官如何有助于空间定向。此外，该实验旨在模拟伴随视觉和前庭信息在空间中的物理旋转和平移的大脑动力学，以及这些信息如何促进空间更新。最后，研究源自脾后复合体（RSC）或其附近的脑动力学，将有助于确定该结构的潜在不同计算功能，RSC是空间定向的核心大脑结构。为此，我们将在一系列实验中比较主动的物理空间定向和视觉流定向。为了记录移动空间定向脑电图（EEG）过程中的大脑动态，将同步进行全身动作捕捉和头戴式虚拟现实。为了对记录的活动进行成像，数据驱动的分析方法将用于研究人类大脑动力学、物理运动和认知过程之间的相互依赖关系。在过去的十年里，记录技术的发展使得人们可以在标准的实验室环境之外记录移动参与者的脑电图活动。数据驱动的分析方法被开发出来，允许分离大脑和非大脑活动。尽管有这些发展，研究人类认知的标准方法要求参与者避免运动，并专注于传感器层面的分析。为了进一步了解与我们的身体结构紧密相关的自然认知过程所伴随的大脑动力学，我们建议对积极运动参与者的空间定向过程中的大脑动力学进行成像。脑动力学成像必须提供有关特定皮层结构何时表现出与认知和行为方面相关的系统性活动变化的信息。电生理数据提供了必要的时间分辨率，以提供对信息处理时间过程的精确见解。脑动力学伴随空间定向整合运动相关的独特反馈是未知的。本课题旨在利用移动脑/体成像技术，克服现有空间定向脑成像研究的局限性。这将有助于我们得出以下结论：大脑是如何表征个体信息的，这些信息是如何用于空间定位的，以及个体信息处理的大脑动态如何导致空间任务中的个体差异。