MitoBalance: Uncovering the mechanisms underlying mitochondrial proteostasis

编码线粒体蛋白的基因突变是许多人类疾病的基础，更多的疾病不断被发现。此外，线粒体功能的逐渐下降在衰老和复杂的疾病表型，如神经变性和癌症中也起到了作用。我们的团队聚集了具有互补专业知识的科学家，他们分享了对了解线粒体和细胞环境之间的相互作用的热情。我们建议利用这一统一的机会，为线粒体生物学中一个尚未探索的方面提供新的曙光--线粒体和细胞的相互作用如何促进健康和疾病中线粒体蛋白质组的动态平衡(蛋白质稳定)。

Mutations in genes encoding mitochondrial proteins underlie many human diseases with more constantly being discovered. In addition gradual decline in mitochondrial function plays a role in aging and complex disease phenotypes such as neurodegeneration and cancer. Our group brings together scientist with complementary expertise that share a passion for understanding the cross talk of mitochondria and the cellular environment. We propose to use this unifying opportunity to shine a new light on an unexplored aspect of mitochondrial biology – how the cross talk of mitochondria and the cell promotes homeostasis of the mitochondrial proteome(proteostasis) in health and disease.