MitoBalance: Uncovering the mechanisms underlying mitochondrial proteostasis

MitoBalance：揭示线粒体蛋白质稳态的机制

• 批准号: 323127228
• 负责人: Professor Dr. Doron Rapaport
• 金额: --
• 依托单位: Interfakultäres Institut für Biochemie (IFIB)
• 依托单位国家: 德国
• 项目类别: DIP Programme
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/323127228?language=en
• 关键词: MitoBalance; Uncovering; mechanisms; underlying; mitochondrial

Mutations in genes encoding mitochondrial proteins underlie many human diseases with more constantly being discovered. In addition gradual decline in mitochondrial function plays a role in aging and complex disease phenotypes such as neurodegeneration and cancer. Our group brings together scientist with complementary expertise that share a passion for understanding the cross talk of mitochondria and the cellular environment. We propose to use this unifying opportunity to shine a new light on an unexplored aspect of mitochondrial biology – how the cross talk of mitochondria and the cell promotes homeostasis of the mitochondrial proteome(proteostasis) in health and disease.

编码线粒体蛋白质的基因突变是许多人类疾病的基础，并且不断被发现。此外，线粒体功能的逐渐下降在衰老和复杂疾病表型如神经变性和癌症中起作用。我们的团队汇集了具有互补专业知识的科学家，他们对理解线粒体和细胞环境的相互作用充满热情。我们建议利用这个统一的机会，在线粒体生物学的一个未探索的方面-线粒体和细胞的串扰如何促进健康和疾病中线粒体蛋白质组的稳态（蛋白质稳态）上闪耀新的光芒。