MitoBalance: Uncovering the mechanisms underlying mitochondrial proteostasis

编码线粒体蛋白质的基因突变是许多人类疾病的基础，并且不断被发现。此外，线粒体功能的逐渐下降在衰老和复杂疾病表型如神经变性和癌症中起作用。我们的团队汇集了具有互补专业知识的科学家，他们对理解线粒体和细胞环境的相互作用充满热情。我们建议利用这个统一的机会，在线粒体生物学的一个未探索的方面-线粒体和细胞的串扰如何促进健康和疾病中线粒体蛋白质组的稳态（蛋白质稳态）上闪耀新的光芒。

Mutations in genes encoding mitochondrial proteins underlie many human diseases with more constantly being discovered. In addition gradual decline in mitochondrial function plays a role in aging and complex disease phenotypes such as neurodegeneration and cancer. Our group brings together scientist with complementary expertise that share a passion for understanding the cross talk of mitochondria and the cellular environment. We propose to use this unifying opportunity to shine a new light on an unexplored aspect of mitochondrial biology – how the cross talk of mitochondria and the cell promotes homeostasis of the mitochondrial proteome(proteostasis) in health and disease.