CKD患者における運動の抑うつ改善効果とその機序の解明：FGF21に着目して

阐明运动对 CKD 患者抑郁的改善作用及其机制：聚焦 FGF21

• 批准号: 20J20892
• 负责人: 松井 公宏
• 金额: $ 1.6万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-24 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20J20892/
• 关键词: CKD; FGF21; 抑うつ症状; 腎臓リハビリテーション; 身体活動; うつ病; 運動

近年，世界的に増加している慢性腎臓病（CKD: chronic kidney disease）患者では，20～30%がうつ病を合併しているとされ，一般的な集団の罹患率（4～8%）に比べ顕著に高い．CKD患者における高いうつ病罹患率には，腎機能低下に伴う血中線維芽細胞増殖因子21（FGF21: fibroblast growth factor 21）濃度の上昇が関与している可能性が考えられる．一方，定期的な運動は血中FGF21濃度を低下させるとともに，うつ病の予防・改善に有効であることが知られている．本研究では，CKD患者における運動が抑うつ症状に及ぼす影響およびその機序について，FGF21に着目して検討した．本研究では，まず，腎機能が低下した中高齢者191名を対象に身体活動量と血中FGF21濃度および抑うつ症状の関連性を検討した．その結果，中高強度身体活動時間が長いほど，血中FGF21濃度は低く，抑うつ症状の程度も低いことが明らかになった．一方で，血中FGF21濃度と抑うつ症状の間に関連性は認められなかった．加えて，腎機能が低下した中高齢者を対象に，日常生活における中高強度身体活動（≧3.0 METs）の時間を増加させる8週間の介入が血中FGF21濃度および抑うつ症状に及ぼす影響について検討した．その結果，介入群では日常生活における中高強度身体活動時間が1日当たり20分間程度増加し，抑うつ症状は介入の前後で改善した．しかし，血中FGF21濃度は介入の前後で有意な変化を示さず，血中FGF21濃度と抑うつ症状の変化量に関連性は認められなかった．本研究の結果から，中高齢者における身体活動は抑うつ症状の改善に貢献する可能性が示されたが，その機序に関しては今後の研究で詳細に研究する必要があると考えられる．

In recent years, 20% to 30% of the patients with chronic infectious diseases (CKD: chronic kidney disease) in the world have suffered from chronic diseases. The attack rate of the general population (40.8%) is higher than that of other diseases. On the one hand, regular exercise shows that the level of FGF21 in the blood is low, the level of FGF21 in the blood is low, and the disease can be prevented and improved. on the one hand, regular exercise tests show that the level of FGF21 in blood is low, and the disease can be prevented and improved. In patients with CKD, the symptoms and symptoms of exercise inhibition were detected, and the sequence of symptoms and shadow tests were monitored by FGF21. In this study, the results showed that the levels of FGF21 in the blood of patients with moderate and high levels of physical activity were constant, and the levels of FGF21 in blood were low. The results showed that the time of moderate and high intensity physical activity was prolonged, and the level of FGF21 in blood was low. The severity of the symptoms is low, the symptoms are low, and the symptoms are low. On the one hand, the FGF21 level in the blood suppresses the symptoms, the symptoms are linked, the symptoms are linked, the symptoms are low, and the machine can reduce the symptoms of those with high levels in the air. During daily life exercise, high intensity physical activity (METs) increased 8 minutes after intervention, FGF21 concentration in blood was reduced, symptoms were suppressed and symptoms were decreased. The results showed that the time for high intensity physical activity in the intervention group was increased at 20 minutes on the 1st day, and the symptoms were improved after intervention. Before and after the intervention of FGF21 levels in the blood, there were intentional changes in the levels of FGF21 in the blood, and the symptoms were suppressed. The results of this study showed that the possibility of improving the symptoms of physical activity inhibition in middle and high school students showed that it was important to study the symptoms in the future.

项目成果

Circulating fibroblast growth factor 21, renal function, and aortic hemodynamics in middle-aged and older adults: a mediation analysis

中老年人循环成纤维细胞生长因子21、肾功能和主动脉血流动力学：中介分析

• 发表时间: 2021
• 作者: Masahiro Matsui;Keisei Kosaki;Makoto Kuro-o;Chie Saito;Kunihiro Yamagata;Seiji Maeda
• 通讯作者: Seiji Maeda

Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults

• DOI: 10.1016/j.exger.2020.111081
• 发表时间: 2020-11-01
• 期刊: EXPERIMENTAL GERONTOLOGY
• 影响因子: 3.9
• 作者: Matsui, Masahiro;Kosaki, Keisei;Maeda, Seiji
• 通讯作者: Maeda, Seiji

Association between circulating FGF21 levels and physical activity in abdominal obese adults

腹部肥胖成人循环 FGF21 水平与体力活动之间的关联

• 发表时间: 2020
• 作者: Masahiro Matsui;Keisei Kosaki;Koichiro Tanahashi;Nobuhiko Akazawa;Yosuke Osuka;Kiyoji Tanaka;Makoto Kuro-o;Seiji Maeda
• 通讯作者: Seiji Maeda

肥満男性における定期的な有酸素性運動が血中FGF21濃度に与える影響

规律有氧运动对肥胖男性血FGF21浓度的影响

• 发表时间: 2021
• 作者: 松井 公宏;小﨑 恵生;妙圎園 香苗;吉川 徹;朴 ジヨン;黒尾 誠;前田 清司
• 通讯作者: 前田 清司

Effect of aerobic exercise training on circulating fibroblast growth factor 21 response to glucose challenge

有氧运动训练对循环成纤维细胞生长因子 21 对葡萄糖挑战反应的影响

• 发表时间: 2022
• 作者: Matsui M;Kosaki K;Myoenzono K;Yoshikawa T;Park J;Kuro-o K;Maeda S.
• 通讯作者: Maeda S.