Diffusional properties of proteins in a bacterial cell (P16)

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The aim of this study is to quantitatively characterize protein diffusion in all four sub-cellular compartments of Gram-negative bacteria. Using gut bacterium Escherichia coli as a model organism, we will study how mobility of proteins of different size and shape is affected by cellular environment and cellular state as well as by environmental factors. This analysis should provide quantitative insights into organization of a bacterial cell and thereby to enable more precise mathematical description of spatiotemporal dynamics of cellular processes.