Diffusional properties of proteins in a bacterial cell (P16)

细菌细胞中蛋白质的扩散特性（P16）

• 批准号: 326620752
• 金额: --
• 依托单位: Abteilung System- und Synthetische Mikrobiologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/326620752?language=en
• 关键词: Diffusional; properties; proteins; bacterial; cell

The aim of this study is to quantitatively characterize protein diffusion in all four sub-cellular compartments of Gram-negative bacteria. Using gut bacterium Escherichia coli as a model organism, we will study how mobility of proteins of different size and shape is affected by cellular environment and cellular state as well as by environmental factors. This analysis should provide quantitative insights into organization of a bacterial cell and thereby to enable more precise mathematical description of spatiotemporal dynamics of cellular processes.

本研究的目的是定量表征蛋白质扩散在所有四个亚细胞室的革兰氏阴性细菌。我们将以肠道细菌大肠杆菌为模式生物，研究不同大小和形状的蛋白质的移动性如何受到细胞环境和细胞状态以及环境因素的影响。这种分析应该提供对细菌细胞组织的定量见解，从而使细胞过程的时空动态的更精确的数学描述成为可能。