Association between genetic polymorphisms of melatonin receptor and psycho-physiological effects of simulated night shift work

褪黑激素受体基因多态性与模拟夜班心理生理效应的关系

• 批准号: 19H03316
• 负责人: 樋口 重和
• 金额: $ 11.07万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19H03316/
• 关键词: 光環境; 概日リズム; 夜勤・交代制勤務; メラトニン受容体; 遺伝子多型; 睡眠; 交代制勤務

前年と同様のプロトコルで模擬的夜勤実験を実施した。被験者10名のデータを追加し、合計35名の若年成人男性のデータを解析に用いた。模擬的夜勤による概日リズム、眠気、パフォーマンスへの影響と先行研究で夜勤者の燃え尽き症候群と関連があることが報告されているメラトニン受容体1A遺伝子（MTNR１A）の近傍にあるrs12506228の一塩基多型と関連を調べた。実験は3泊4日とし、実験の1週間前から睡眠統制を行った。実験1日目は、概日リズム位相の指標であるメラトニンの分泌開始時刻（DLMO: Dim Light Melatonin Onset）を調べた。2日目は、21時から翌日の9時まで、12時間の模擬的夜勤を行った。夜勤中は精神課題を実施するとともに、眠気や疲労に関する自覚症状を調べた。3日目の夜は、夜勤による概日リズム位相の後退量を調べるために、1日目と同様にDLMOを測定した。DLMOの検出ができた28名について、Aアレル保有群（n=12）と非保有群(n=16)に分けて分析を行った。夜勤による概日リズムの位相は両群ともに有意に後退したが、後退量には群間で差があり、保有群の方が有意に大きかった。夜勤中の「眠気」は、両群とも有意に増加したが、群間に有意差は無かった。自覚症しらべの「だるさ感」は、非保有群では夜勤後半で有意に増加したが保有群では夜勤を通して変化しなかった。以上の結果から、先行研究で燃え尽き症候群と関連のあるとされているrs12506228のAアレル保有群は、一晩の模擬的夜勤で概日リズムの位相が後退しやすく、夜勤中の疲労に気がつきにくい可能性が高いことが示唆された。これらの成果について学会発表を行った。

The year before last, the same night shift was carried out. 10 of the victims were added, totaling 35 adult males. A preliminary study on the effects of simulated night attendance on night attendance syndrome and correlation was conducted. The correlation between night attendance syndrome and correlation was reported. The correlation between receiver 1A gene (MTNR1A) and its neighborhood was adjusted. 3 days ago, 4 days ago, 1 week ago, sleep control was performed. 1. The index of the phase is adjusted according to DLMO (Dim Light Melatonin Onset). 2 days, 21 hours, 9 hours the next day, 12 hours, simulated night shift. Night work is a mental problem, sleep is a problem, and sleep is a problem. 3 days of night, night shift, day shift DLMO was identified by 28 sub-groups, A sub-groups (n=12) and non-sub-groups (n=16). In the evening, the group is divided into two groups: the group is divided into three groups: the group is divided into two groups: the group is divided into three groups: the group is divided into two groups: the group is divided into three groups: the group is divided into two groups: the group is divided into three groups: the group is divided into four groups: the group is divided into three groups: the group is divided into three groups: the group is divided into four groups: the group is divided into three groups: the group is divided into four groups: the group is divided into three groups: the group is divided into four groups: the group is divided into three groups: the group is divided into four groups: the group is divided into three groups; the group is divided into three groups is divided into four groups: the group is divided into four groups: the group is divided into three groups; the group is divided into four groups is divided into four groups: the group is divided into three groups; the group is divided into four groups; the group is divided Night work in the "sleep", the group intentionally increased, the group intentionally different Since the disease, the "feeling" has not been maintained, the second half of the night has been intentionally increased, and the night has been maintained. The results of the above study are as follows: the first study is to study the exhaustion syndrome and the correlation between them, and the first study is to study the exhaustion syndrome and the correlation between them. The results of this study were published in the journal Science and Technology.

项目成果

光と睡眠とサーカディアンリズム

光线、睡眠和昼夜节律

• 发表时间: 2019
• 作者: Mizuki Fujibayashi;Takuto Kawaji and Kentaro Abe;古賀章彦;水野佑紀，増岡弘晃，木部未帆子，小坂理子，夏原和美，平山和宏，Nouhak Inthavong，Sengchanh Kounnavong，富田晋介，梅崎昌裕．;樋口重和
• 通讯作者: 樋口重和

一晩の模擬的夜勤による耐糖能への影響

夜间模拟夜班对糖耐量的影响

• 发表时间: 2020
• 作者: 佐藤燦斗;眞子杜都;河野寛之;大橋路弘;江藤太亮;元村祐貴;樋口重和
• 通讯作者: 樋口重和

Melatonin suppression during a simulated night shift in medium intensity light is increased by 10-minute breaks in dim light and decreased by 10-minute breaks in bright light

• DOI: 10.1080/07420528.2020.1752704
• 发表时间: 2020-04-25
• 期刊: CHRONOBIOLOGY INTERNATIONAL
• 影响因子: 2.8
• 作者: Lee, Sang-Il;Kinoshita, Saki;Higuchi, Shigekazu
• 通讯作者: Higuchi, Shigekazu

光環境への適応

适应光环境

• 发表时间: 2019
• 作者: Goto Fumiko;Kiyama Yuji;Ogawa Itone;Okuno Hiroyuki;Ichise Taeko;Ichise Hirotake;Anai Motonobu;Kodama Tatsuhiko;Yoshida Nobuaki;Bito Haruhiko;Manabe Toshiya;梅﨑昌裕;樋口重和
• 通讯作者: 樋口重和

ipRGCの発見と概日リズム研究の発展

ipRGC的发现与昼夜节律研究的进展

• 发表时间: 2021
• 期刊: 日本色彩学会誌
• 作者: 江藤 太亮;樋口 重和
• 通讯作者: 樋口 重和