Identification of cytokines responsible for the development of immune-mediated bone marrow failure using gene expression analyses of patients with aplastic anemia

利用再生障碍性贫血患者的基因表达分析来鉴定导致免疫介导的骨髓衰竭发生的细胞因子

• 批准号: 25670448
• 负责人: NAKAO Shinji
• 金额: $ 2.41万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25670448/
• 关键词: 再生不良性貧血; 造血抑制性サイトカイン; インターロイキン１０; CXCL12; クローン性造血; マイクロアレイ; 発作性夜間血色素尿症; ゲノム変異; NFAT; Nr4a; シクロスポリン; エクソームシーケンシング

项目成果

Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.

• DOI: 10.1056/nejmoa1414799
• 发表时间: 2015-07-02
• 期刊: The New England journal of medicine
• 作者: Yoshizato T;Dumitriu B;Hosokawa K;Makishima H;Yoshida K;Townsley D;Sato-Otsubo A;Sato Y;Liu D;Suzuki H;Wu CO;Shiraishi Y;Clemente MJ;Kataoka K;Shiozawa Y;Okuno Y;Chiba K;Tanaka H;Nagata Y;Katagiri T;Kon A;Sanada M;Scheinberg P;Miyano S;Maciejewski JP;Nakao S;Young NS;Ogawa S
• 通讯作者: Ogawa S

Hematopoiesis in Patients with Acquired Aplastic Anemia Is Supported By a Limited Number of CXCR4(-) Cells at the Common Myeloid Progenitor Level

获得性再生障碍性贫血患者的造血功能由髓系祖细胞水平上有限数量的 CXCR4(-) 细胞支持

• 发表时间: 2014
• 作者: Takamasa Katagiri;Atsuo Kasada;Kana Motomiya;Yoshitaka Zaimoku;An T. T. Dao;Hiroyuki Maruyama;Ken Ishiyama;Shigeki Ohtake;Atsushi Hirao;Shinji Nakao
• 通讯作者: Shinji Nakao

IncreasedHigh gene expression of Nr4A family in bone marrow T cells is associated with rapid response after ISTto cyclosoporine in the patients with non-severeearly stage acuired aplastic anemia

骨髓T细胞中Nr4A家族基因高表达与非重度早期急性再生障碍性贫血患者IST对环孢素后的快速反应相关

• 发表时间: 2013
• 作者: Kohei Hosokawa;Takumi Nishiuchi;Takamasa Katagiri;Chizuru Saito;Hiroyuki Maruyama;Naomi Sugimori;Hirohito Yamazaki;Shinji Nakao
• 通讯作者: Shinji Nakao

Imatinib for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation.

伊马替尼治疗异基因造血干细胞移植后闭塞性细支气管炎。

• 发表时间: 2015
• 期刊: Bone Marrow Transplant
• 作者: Watanabe S;Waseda Y;Kimura H;Takato H;Ohata K;Kondo Y;Kasahara K;Nakao S.
• 通讯作者: Nakao S.

Induction of HLA-B*40:02-restricted T cells possessing cytotoxic and suppressive functions against hematopoietic progenitor cells from a patient with severe aplastic anemia.

从患有严重再生障碍性贫血的患者中诱导具有细胞毒性和抑制造血祖细胞功能的 HLA-B*40:02 限制性 T 细胞。

• 发表时间: 2015
• 期刊: Br J Haematol
• 作者: Inaguma Y;Akatsuka Y;Hosokawa K;Maruyama H;Okamoto A;Katagiri T;Shiraishi K;Murayama Y;Tsuzuki-Iba S;Mizutani Y;Nishii C;Yamamoto N;Demachi-Okamura A;Kuzushima K;Ogawa S;Emi N;Nakao S.
• 通讯作者: Nakao S.