Identification of myelosuppressive cytokines taking advantage of genomic abnormalities of leukocytes in patients with aplastic anemia

利用再生障碍性贫血患者白细胞基因组异常鉴定骨髓抑制细胞因子

• 批准号: 24390243
• 负责人: NAKAO Shinji
• 金额: $ 11.48万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24390243/
• 关键词: 再生不良性貧血; クロナリティ; 免疫抑制療法; 細胞傷害性T細胞; 片親性二倍体; クローン性造血; ゲノム変異; 6pUPD; SLIT1; CD109; HLA-B*40:02; HLA-Aアレル欠失血球; エスケープ造血; 可溶性HLAペプチドーム

项目成果

Increased plasma thrombopoietin levels in patients with myelodysplastic syndrome: a reliable marker for a benign subset of bone marrow failure

• DOI: 10.3324/haematol.2012.066217
• 发表时间: 2013-06-01
• 期刊: HAEMATOLOGICA
• 影响因子: 10.1
• 作者: Seiki, Yu;Sasaki, Yumi;Nakao, Shinji
• 通讯作者: Nakao, Shinji

Evidence That HLA-B*40:02 and HLA-Α*31:01 Are Strongly Involved in the Presentation of Autoantigens to CTLs Responsible for the Development of Acquired Aplastic Anemia

HLA-B*40:02 和 HLA-A*31:01 强烈参与向 CTL 呈递自身抗原，从而导致获得性再生障碍性贫血的证据

• 发表时间: 2014
• 作者: Yoshitaka Zaimoku;Hiroyuki Maruyama;Kana Maruyama;Takamasa Katagiri;An T. T. Dao;Hiroyuki Takamatsu;Hirohito Yamazaki;Koichi Kashiwase;Shinji Nakao.
• 通讯作者: Shinji Nakao.

Detection of leukocytes lacking HLA-A alleles by flow cytometry predicts a response to immunosuppressive therapy in patients with acquired aplastic anemia.

通过流式细胞术检测缺乏 HLA-A 等位基因的白细胞可以预测获得性再生障碍性贫血患者对免疫抑制治疗的反应。

• 作者: Hiroyuki Maruyama;Takamasa Katagiri;Kohei Hosokawa;Chizuru Saito;Hirohito Yamazaki;Shinji Nakao
• 通讯作者: Shinji Nakao

SLIT1 mutation in patients with acquired aplastic anemia : Its relevance in immune pathophysiology.

获得性再生障碍性贫血患者的 SLIT1 突变：其与免疫病理生理学的相关性。

• 发表时间: 2012
• 作者: Sakaguchi H;Yoshida K;Chizuru Saito
• 通讯作者: Chizuru Saito

Imatinib for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation.

伊马替尼治疗异基因造血干细胞移植后闭塞性细支气管炎。

• 发表时间: 2015
• 期刊: Bone Marrow Transplant
• 作者: Watanabe S;Waseda Y;Kimura H;Takato H;Ohata K;Kondo Y;Kasahara K;Nakao S.
• 通讯作者: Nakao S.