Identification of novel auto-antibodies and corresponding antigens in patients with aplastic anemia using CLIP replacement Ii chain library

使用CLIP替换Ii链文库鉴定再生障碍性贫血患者的新型自身抗体和相应抗原

• 批准号: 19390260
• 负责人: NAKAO Shinji
• 金额: $ 11.07万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390260/
• 关键词: 再生不良性貧血; hnRNPK; DRS-1; moesin; 免疫抑制療法; 自己抗体; モエシン; 慢性関節リウマチ

再生不良性貧血(再不貧)における新たな自己抗原を同定するため、造血幹細胞由来の蛋白を再不貧患者血清と反応させたところ、heterogenous nuclear ribonucleoprotein(hnRNPK)に対する抗体が同定された。この抗hnRNP抗体は自己免疫性再生不良性貧血(再不貧)で高頻度に検出されることが明らかになった。この抗体は再不貧患者の約30%に検出され、陽性患者では免疫抑制療法に対する反応性が、陰性患者に比べて有意に高かった。したがって本抗体は再不貧における免疫病態の良いマーカーと考えられた。

Aplastic anemia (AA) is characterized by the presence of new antigens, hematopoietic stem cell-derived proteins, and antibodies to heterogenous nuclear ribonucleoprotein(hnRNPK). The anti-hnRNP antibody was detected with high frequency in autoimmune aplastic anemia (AA). These antibodies were detected in approximately 30% of patients who were no longer poor. Positive patients were resistant to immunosuppressive therapy and negative patients were intentionally higher. The antibody is not poor anymore.

项目成果

Roles of DRB1*1501 and DRB1*1502 in the pathogenesis of aplastic anemia

• DOI: 10.1016/j.exphem.2006.09.002
• 发表时间: 2007-01-01
• 期刊: EXPERIMENTAL HEMATOLOGY
• 影响因子: 2.6
• 作者: Sugimori, Chiharu;Yamazaki, Hirohito;Nakao, Shinji
• 通讯作者: Nakao, Shinji

Cyclosporine Therapy for Acquired Aplastic Anemia: Predictive Factors for the Response and Long-term Prognosis

• DOI: 10.1532/ijh97.06156
• 发表时间: 2007-04
• 期刊: International Journal of Hematology
• 影响因子: 2.1
• 作者: H. Yamazaki;C. Sugimori;T. Chuhjo;S. Nakao

Aberrant increase in the immature platelet fraction in patients with myelodysplastic syndrome : a marker of karyotypic abnormalities associated with poor prognosis Eur J Haematol

骨髓增生异常综合征患者未成熟血小板分数异常增加：与不良预后相关的核型异常标志 Eur J Haematol

• 发表时间: 2009
• 期刊: 82
• 作者: Sugimori N;Kondo Y;Shibayama M;Omote M;Takami A;Sugimori C;Ishiyama K;Yamazaki H;Nakao S
• 通讯作者: Nakao S

Autoantibodies specific to hnRNP K : a new diagnostic marker for immune pathophysiology in bone marrow failure syndromes.

hnRNP K 特异性自身抗体：骨髓衰竭综合征免疫病理生理学的新诊断标记物。

• 发表时间: 2008
• 作者: Zhirong Qi;Nakao S;et al
• 通讯作者: et al

Treatment of severe aplastic anemia with antithymocyte globulin and cyclosporin A with or without G-CSF in adults : a multicenter randomized study in Japan

用抗胸腺细胞球蛋白和环孢素 A 联合或不联合 G-CSF 治疗成人严重再生障碍性贫血：日本的一项多中心随机研究

• 发表时间: 2007
• 期刊: Blood 110
• 作者: Teramura M;Kimura A;Iwase S;Yonemura Y;Nakao S;Urabe A;Omine M;Mizoguchi H
• 通讯作者: Mizoguchi H