Continuous noninvasive tissue temperature monitoring inside of the human body during hyperthermia based on ultra-wideband microwave sensing

基于超宽带微波传感的热疗过程中人体内部连续无创组织温度监测

基本信息

  • 批准号:
    336022083
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    德国
  • 项目类别:
    Research Grants
  • 财政年份:
    2017
  • 资助国家:
    德国
  • 起止时间:
    2016-12-31 至 2018-12-31
  • 项目状态:
    已结题

项目摘要

This German-Czech research project (cooperation with Prof. Jan Vrba, CTU Prague) aims for the development of a non-invasive continuous tissue temperature measurement and imaging technique inside the human body by means of ultra-wideband (UWB) microwave sensing. Such systems are of utmost clinical importance, especially for temperature monitoring during hyperthermia. Previously proposed approaches of non-invasive temperature measurement could not be established in the clinical workflow so far. That is why invasive temperature probes are still in use despite their associated risks. The goal of this project is a new non-invasive method exploiting the temperature dependent tissue permittivity over a very broad frequency range (about 6 GHz) for temperature measurement and estimation, respectively. The primary envisaged application field is hyperthermia treatment. Beyond that, this project aims to contribute to force the application of this cost efficient and compact sensor technology for non-invasive accurate clinical tissue temperature monitoring in general.The following topics will be addressed to solve this innovative task:- Temperature dependent dielectric microwave spectroscopy of tissue, tissue imitates and magnetic nanoparticle (MNP) suspensions- Conceptual design of the UWB measurement system (especially antenna design) and optimization of working conditions (polarization, bandwidth) for use during microwave hyperthermia treatment- Extraction and analysis of temperature dependent UWB signatures- Development of real-time capable signal processing for robust detection and quantification of temperature changes inside of tissue considering drift, movement artifacts, tissue heterogeneity and perfusion- 3D imaging of temperature distribution in homogeneous and heterogeneous phantoms
该德国-捷克研究项目(与布拉格CTU的Jan弗尔巴教授合作)旨在通过超宽带(UWB)微波传感开发人体内的无创连续组织温度测量和成像技术。这样的系统具有极其重要的临床意义,特别是对于热疗期间的温度监测。以前提出的非侵入性温度测量方法至今无法在临床工作流程中建立。这就是为什么尽管有相关风险,但侵入式温度探头仍在使用。该项目的目标是一种新的非侵入性方法,利用温度依赖的组织介电常数在一个非常宽的频率范围(约6 GHz)的温度测量和估计,分别。主要设想的应用领域是热疗治疗。除此之外,该项目旨在推动这种具有成本效益和紧凑型传感器技术在非侵入性精确临床组织温度监测中的应用。将解决以下主题以解决这一创新任务:- 组织、组织模拟物和磁性纳米颗粒(MNP)悬浮液的温度相关介电微波光谱学-UWB测量系统的概念设计(特别是天线设计)和优化工作条件(极化,微波热疗治疗用超宽带信号的提取和分析真实的考虑到漂移、运动伪影组织异质性和灌注-均质和异质体模中温度分布的3D成像

项目成果

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Dr.-Ing. Marko Helbig其他文献

Dr.-Ing. Marko Helbig的其他文献

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{{ truncateString('Dr.-Ing. Marko Helbig', 18)}}的其他基金

ultraMAMMA II - Dynamic UWB microwave imaging for breast cancer detection
ultraMAMMA II - 用于乳腺癌检测的动态 UWB 微波成像
  • 批准号:
    241894440
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
    Research Grants

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