Effects of repetitive magnetic stimulation on synaptic plasticity deficits in hepatic encephalopathy - cellular and molecular mechanisms (B11#)

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Hepatic Encephalopathy (HE) is associated with alterations in the ability of neurons to express synaptic plasticity. This project evaluates the effects of repetitive Transcranial Magnetic Stimulation (rTMS) on HE-associated alterations of glial and neuronal mediators of homeostatic and associative synaptic plasticity in mouse organotypic slice cultures. The results will provide new important insights on the cellular and molecular mechanisms of HE-associated alterations in synaptic plasticity and may pave the way toward a diagnostic and therapeutic use of rTMS in HE-patients.