Effects of repetitive magnetic stimulation on synaptic plasticity deficits in hepatic encephalopathy - cellular and molecular mechanisms (B11#)

重复磁刺激对肝性脑病突触可塑性缺陷的影响 - 细胞和分子机制（B11）

• 批准号: 336086942
• 金额: --
• 依托单位: Institut für Anatomie und Zellbiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/336086942?language=en
• 关键词: Effects; repetitive; magnetic; stimulation; synaptic

Hepatic Encephalopathy (HE) is associated with alterations in the ability of neurons to express synaptic plasticity. This project evaluates the effects of repetitive Transcranial Magnetic Stimulation (rTMS) on HE-associated alterations of glial and neuronal mediators of homeostatic and associative synaptic plasticity in mouse organotypic slice cultures. The results will provide new important insights on the cellular and molecular mechanisms of HE-associated alterations in synaptic plasticity and may pave the way toward a diagnostic and therapeutic use of rTMS in HE-patients.

肝性脑病（HE）与神经元表达突触可塑性的能力改变有关。该项目评估了重复经颅磁刺激 (rTMS) 对小鼠器官切片培养物中稳态神经胶质和神经元介质的 HE 相关改变和关联突触可塑性的影响。这些结果将为 HE 相关突触可塑性改变的细胞和分子机制提供新的重要见解，并可能为 rTMS 在 HE 患者中的诊断和治疗应用铺平道路。