Effect of modification of structural and cellular properties of the arterial wall on functional stiffness of large arteries

动脉壁结构和细胞特性的改变对大动脉功能刚度的影响

• 批准号: DP0773971
• 负责人: Prof Alberto Avolio
• 金额: $ 20.11万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0773971
• 关键词: Effect; modification; structural; cellular; properties

The Australian population is ageing, becoming more obese and showing earlier onset of age-related conditions such as high blood pressure, heart failure and inflammatory disorders. All these conditions are associated with possible increase arterial stiffness. Inflammatory disorders in Australia affect one in six people, increasing to one in five in the next decade. An equal proportion is affected by cardiovascular disease. This combined effect poses a massive burden on the national health budget. This project aims to investigate basic mechanism leading to degeneration of function of larger arteries and therapies to reverse the process and reduce cardiovascular risk in the community.

澳大利亚人口正在老龄化，变得更加肥胖，并显示出与年龄有关的疾病，如高血压，心力衰竭和炎症性疾病的早期发病。所有这些情况都与可能增加动脉僵硬度有关。澳大利亚的炎症性疾病影响六分之一的人，在未来十年内增加到五分之一。同样比例的人受到心血管疾病的影响。这一综合效应给国家卫生预算造成了巨大负担。该项目旨在研究导致大动脉功能退化的基本机制以及逆转该过程并降低社区心血管风险的治疗方法。