Arterial stiffness: mechanistic role of interaction of cellular processes and the extracellular matrix

动脉僵硬度：细胞过程和细胞外基质相互作用的机械作用

• 批准号: DP110101134
• 负责人: Prof Alberto Avolio
• 金额: $ 26.01万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP110101134
• 关键词: Arterial; stiffness; mechanistic; role; interaction

Arterial stiffness causes high blood pressure with age, so with more people living longer it is important to understand why arteries become stiff. This investigation uses genetically engineered mice to study how changes in nitric oxide in the cells of the artery wall can lead to changes in the wall material and so affect arterial stiffness.

随着年龄的增长，动脉硬化会导致高血压，因此随着越来越多的人寿命的延长，了解动脉硬化的原因非常重要。这项研究使用基因工程小鼠来研究动脉壁细胞中一氧化氮的变化如何导致壁材料的变化，从而影响动脉硬度。