Vascular and neurogenic determinants of hypertension in chronic kidney disease

慢性肾病高血压的血管和神经源性决定因素

• 批准号: nhmrc : 1030297
• 负责人: Prof Alberto Avolio
• 金额: $ 33.88万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/vascular-neurogenic-determinants-kidney-disease/110746
• 关键词: Vascular; neurogenic; determinants; hypertension; chronic

You are as old as your arteries, and people with kidney disease have arteries that age fast. They also have overactive sympathetic nerves, and it is not clear if the blood vessels or nerves are responsible for the high blood pressure that puts strain on the heart and other organs of these patients. We will use an animal model to determine if therapy for hypertension reduces the stiffness of blood vessels or elevated nerve activity. Our results will enable better treatments for kidney failure.

你的年龄和你的动脉一样大，患有肾脏疾病的人的动脉老化得很快。他们也有过度活跃的交感神经，目前还不清楚血管或神经是否是造成高血压的原因，高血压会给这些患者的心脏和其他器官带来压力。我们将使用动物模型来确定高血压的治疗是否会降低血管的硬度或增加神经活动。我们的研究结果将使更好的治疗肾衰竭。